FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097912559> ?p ?o ?g. }

• W2097912559 endingPage "2542" @default.
• W2097912559 startingPage "2539" @default.
• W2097912559 abstract "Abstract Objectives/Hypothesis: Audiometric patterns have been shown to indirectly provide information regarding the pathophysiology of presbycusis and be useful in the phenotyping of hereditary deafness. Study Design and Methods: Hospital‐based cohort study of adults with presbycusis, comparing the association of audiometric patterns and polymorphisms of antioxidant enzymes that have been linked to presbycusis: GSTT1 , GSTM1 and NAT2 . All subjects underwent a clinical evaluation and completed questionnaires regarding ototoxicity and noise exposure. Pure‐tone threshold audiometry was obtained and subjects' audiograms were classified into specific patterns. DNA was extracted from blood and the polymorphisms of GSTT1 , GSTM1 , and the NAT2 variants ( NAT2 * 5A ; NAT2 * 6A , B ) were analyzed by PCR. Results: The audiometric patterns that were more prevalent in our cohort were “High‐Frequency Steeply Sloping” or HFSS (33%), “High‐Frequency Gently Sloping” or HFGS (31%), and “Flat” (27%), with other patterns being rare. We did not find a statistical significant effect of gender, age, hearing level, and ear side on the audiometric pattern. Subjects with mutant alleles for GSTT1 were more likely to have a HFSS audiogram than subjects with the wild type genotype. Conclusions: In this cohort, there was a similar prevalence for the three audiometric configurations HFSS, HFGS, and Flat, with other configurations being rare. Subjects with mutant alleles for GSTT1 were more likely to have a HFSS audiogram than subjects with the wild type genotype, suggesting that the basal turn of the cochlea is susceptible to GSTT1 regulated oxidative stress. However, further studies of audioprofiles with larger sample sizes may be needed to establish phenotype‐genotype correlations in presbycusis. Laryngoscope, 2012" @default.
• W2097912559 created "2016-06-24" @default.
• W2097912559 creator A5013201133 @default.
• W2097912559 creator A5027324455 @default.
• W2097912559 creator A5076451778 @default.
• W2097912559 creator A5081524850 @default.
• W2097912559 creator A5086980934 @default.
• W2097912559 creator A5091621138 @default.
• W2097912559 date "2012-09-10" @default.
• W2097912559 modified "2023-10-18" @default.
• W2097912559 title "Audioprofiles and antioxidant enzyme genotypes in presbycusis" @default.
• W2097912559 cites W1966896260 @default.
• W2097912559 cites W1972037599 @default.
• W2097912559 cites W1975624851 @default.
• W2097912559 cites W1982647833 @default.
• W2097912559 cites W1990223879 @default.
• W2097912559 cites W2000663528 @default.
• W2097912559 cites W2012095162 @default.
• W2097912559 cites W2013514344 @default.
• W2097912559 cites W2031375292 @default.
• W2097912559 cites W2056774798 @default.
• W2097912559 cites W2057620396 @default.
• W2097912559 cites W2078291178 @default.
• W2097912559 cites W2078357046 @default.
• W2097912559 cites W2088841836 @default.
• W2097912559 cites W2090943151 @default.
• W2097912559 cites W2091627632 @default.
• W2097912559 cites W2095786576 @default.
• W2097912559 cites W2163150367 @default.
• W2097912559 cites W2268626592 @default.
• W2097912559 cites W2268695670 @default.
• W2097912559 cites W4239929248 @default.
• W2097912559 doi "https://doi.org/10.1002/lary.23577" @default.
• W2097912559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22965834" @default.
• W2097912559 hasPublicationYear "2012" @default.
• W2097912559 type Work @default.
• W2097912559 sameAs 2097912559 @default.
• W2097912559 citedByCount "15" @default.
• W2097912559 countsByYear W20979125592013 @default.
• W2097912559 countsByYear W20979125592014 @default.
• W2097912559 countsByYear W20979125592015 @default.
• W2097912559 countsByYear W20979125592016 @default.
• W2097912559 countsByYear W20979125592019 @default.
• W2097912559 countsByYear W20979125592020 @default.
• W2097912559 countsByYear W20979125592021 @default.
• W2097912559 countsByYear W20979125592022 @default.
• W2097912559 crossrefType "journal-article" @default.
• W2097912559 hasAuthorship W2097912559A5013201133 @default.
• W2097912559 hasAuthorship W2097912559A5027324455 @default.
• W2097912559 hasAuthorship W2097912559A5076451778 @default.
• W2097912559 hasAuthorship W2097912559A5081524850 @default.
• W2097912559 hasAuthorship W2097912559A5086980934 @default.
• W2097912559 hasAuthorship W2097912559A5091621138 @default.
• W2097912559 hasConcept C104317684 @default.
• W2097912559 hasConcept C126322002 @default.
• W2097912559 hasConcept C135763542 @default.
• W2097912559 hasConcept C17743292 @default.
• W2097912559 hasConcept C2779912225 @default.
• W2097912559 hasConcept C2780493683 @default.
• W2097912559 hasConcept C2780554537 @default.
• W2097912559 hasConcept C54355233 @default.
• W2097912559 hasConcept C548259974 @default.
• W2097912559 hasConcept C71924100 @default.
• W2097912559 hasConcept C72563966 @default.
• W2097912559 hasConcept C86803240 @default.
• W2097912559 hasConceptScore W2097912559C104317684 @default.
• W2097912559 hasConceptScore W2097912559C126322002 @default.
• W2097912559 hasConceptScore W2097912559C135763542 @default.
• W2097912559 hasConceptScore W2097912559C17743292 @default.
• W2097912559 hasConceptScore W2097912559C2779912225 @default.
• W2097912559 hasConceptScore W2097912559C2780493683 @default.
• W2097912559 hasConceptScore W2097912559C2780554537 @default.
• W2097912559 hasConceptScore W2097912559C54355233 @default.
• W2097912559 hasConceptScore W2097912559C548259974 @default.
• W2097912559 hasConceptScore W2097912559C71924100 @default.
• W2097912559 hasConceptScore W2097912559C72563966 @default.
• W2097912559 hasConceptScore W2097912559C86803240 @default.
• W2097912559 hasIssue "11" @default.
• W2097912559 hasLocation W20979125591 @default.
• W2097912559 hasLocation W20979125592 @default.
• W2097912559 hasOpenAccess W2097912559 @default.
• W2097912559 hasPrimaryLocation W20979125591 @default.
• W2097912559 hasRelatedWork W1972037599 @default.
• W2097912559 hasRelatedWork W1973275591 @default.
• W2097912559 hasRelatedWork W2097912559 @default.
• W2097912559 hasRelatedWork W2337989314 @default.
• W2097912559 hasRelatedWork W2415180625 @default.
• W2097912559 hasRelatedWork W2941031040 @default.
• W2097912559 hasRelatedWork W3046606130 @default.
• W2097912559 hasRelatedWork W320415391 @default.
• W2097912559 hasRelatedWork W4224257051 @default.
• W2097912559 hasRelatedWork W2741235893 @default.
• W2097912559 hasVolume "122" @default.
• W2097912559 isParatext "false" @default.
• W2097912559 isRetracted "false" @default.
• W2097912559 magId "2097912559" @default.
• W2097912559 workType "article" @default.