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- W2097918376 abstract "ABSTRACT Many mucosal pathogens invade the host by initially infecting the organized mucosa-associated lymphoid tissue (o-MALT) such as Peyer’s patches or nasal cavity-associated lymphoid tissue (NALT) before spreading systemically. There is no clear demonstration that serum antibodies can prevent infections in o-MALT. We have tested this possibility by using the mouse mammary tumor virus (MMTV) as a model system. In peripheral lymph nodes or in Peyer’s patches or NALT, MMTV initially infects B lymphocytes, which as a consequence express a superantigen (SAg) activity. The SAg molecule induces the local activation of a subset of T cells within 6 days after MMTV infection. We report that similar levels of anti-SAg antibody (immunoglobulin G) in serum were potent inhibitors of the SAg-induced T-cell response both in peripheral lymph nodes and in Peyer’s patches or NALT. This result clearly demonstrates that systemic antibodies can gain access to Peyer’s patches or NALT." @default.
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- W2097918376 date "1999-02-01" @default.
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- W2097918376 title "Systemic Antibodies Can Inhibit Mouse Mammary Tumor Virus-Driven Superantigen Response in Mucosa-Associated Lymphoid Tissues" @default.
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- W2097918376 doi "https://doi.org/10.1128/jvi.73.2.1729-1733.1999" @default.
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