FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097923584> ?p ?o ?g. }

• W2097923584 endingPage "1583" @default.
• W2097923584 startingPage "1574" @default.
• W2097923584 abstract "Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease.The aim of this study was to investigate genetic factors influencing plasma fatty acid distribution in Alaskan Eskimos from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.Fatty acids in plasma were measured by gas chromatography in 761 related individuals (>35 y of age).Quantitative genetic analyses showed that fatty acid distribution is significantly heritable (P < 0.001), with heritabilities ranging from 0.33 to 0.55. A genome-wide scan for plasma fatty acids identified a 20-cM region on chromosome 8 (p12-p21) with a quantitative trait locus for monounsaturated fatty acids (logarithm of odds score = 3.8). The same region had a quantitative trait locus for polyunsaturated fatty acids (logarithm of odds score = 2.6). We genotyped single nucleotide polymorphisms (SNPs) in candidate genes in 8p12-p21 and found a significant association between fatty acids and SNPs in apolipoprotein J (APOJ), lipoprotein lipase (LPL), macrophage scavenger receptor 1 (MSR1), and tumor necrosis factor receptor superfamily member 10b (TNFRSF10B). A Bayesian quantitative trait nucleotide analysis based on a measured genotype model showed that SNPs in LPL, TNFRSF10B, and APOJ had strong statistical evidence of a functional effect (posterior probability > or =75%) on plasma fatty acid distribution.The results indicate that there is strong genetic influence on plasma fatty acid distribution and that genetic variation in APOJ, LPL, and TNFRSF10B may play a role. The GOCADAN study was registered at www.clinicaltrials.gov as NCT00006192." @default.
• W2097923584 created "2016-06-24" @default.
• W2097923584 creator A5001462127 @default.
• W2097923584 creator A5011129933 @default.
• W2097923584 creator A5011148296 @default.
• W2097923584 creator A5018436834 @default.
• W2097923584 creator A5031475597 @default.
• W2097923584 creator A5040670477 @default.
• W2097923584 creator A5057050252 @default.
• W2097923584 creator A5063555195 @default.
• W2097923584 creator A5069964953 @default.
• W2097923584 creator A5074568352 @default.
• W2097923584 creator A5074588571 @default.
• W2097923584 creator A5079020015 @default.
• W2097923584 creator A5083104890 @default.
• W2097923584 creator A5086944853 @default.
• W2097923584 date "2010-06-01" @default.
• W2097923584 modified "2023-10-03" @default.
• W2097923584 title "Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos" @default.
• W2097923584 cites W113548409 @default.
• W2097923584 cites W1519466388 @default.
• W2097923584 cites W1521443934 @default.
• W2097923584 cites W1896934050 @default.
• W2097923584 cites W1955662609 @default.
• W2097923584 cites W1977109672 @default.
• W2097923584 cites W1980050556 @default.
• W2097923584 cites W1992779032 @default.
• W2097923584 cites W1994130453 @default.
• W2097923584 cites W1996697559 @default.
• W2097923584 cites W2000932405 @default.
• W2097923584 cites W2003283414 @default.
• W2097923584 cites W2009465453 @default.
• W2097923584 cites W2036691589 @default.
• W2097923584 cites W2046076301 @default.
• W2097923584 cites W2046801160 @default.
• W2097923584 cites W2048578647 @default.
• W2097923584 cites W2053114866 @default.
• W2097923584 cites W2062318434 @default.
• W2097923584 cites W2078026630 @default.
• W2097923584 cites W2082017580 @default.
• W2097923584 cites W2086969742 @default.
• W2097923584 cites W2095237667 @default.
• W2097923584 cites W2095595424 @default.
• W2097923584 cites W2096998782 @default.
• W2097923584 cites W2098386233 @default.
• W2097923584 cites W2104613016 @default.
• W2097923584 cites W2104743461 @default.
• W2097923584 cites W2105186639 @default.
• W2097923584 cites W2110649959 @default.
• W2097923584 cites W2113727840 @default.
• W2097923584 cites W2115335486 @default.
• W2097923584 cites W2121371688 @default.
• W2097923584 cites W2127141734 @default.
• W2097923584 cites W2127472986 @default.
• W2097923584 cites W2133425349 @default.
• W2097923584 cites W2142769596 @default.
• W2097923584 cites W2144272806 @default.
• W2097923584 cites W2151718403 @default.
• W2097923584 cites W2152119060 @default.
• W2097923584 cites W2160138207 @default.
• W2097923584 cites W2161381425 @default.
• W2097923584 cites W2273510741 @default.
• W2097923584 cites W2281970623 @default.
• W2097923584 cites W2410219672 @default.
• W2097923584 cites W3214092816 @default.
• W2097923584 cites W4211177544 @default.
• W2097923584 cites W1566700100 @default.
• W2097923584 cites W2138137938 @default.
• W2097923584 doi "https://doi.org/10.3945/ajcn.2009.28927" @default.
• W2097923584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2869509" @default.
• W2097923584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410100" @default.
• W2097923584 hasPublicationYear "2010" @default.
• W2097923584 type Work @default.
• W2097923584 sameAs 2097923584 @default.
• W2097923584 citedByCount "26" @default.
• W2097923584 countsByYear W20979235842012 @default.
• W2097923584 countsByYear W20979235842013 @default.
• W2097923584 countsByYear W20979235842014 @default.
• W2097923584 countsByYear W20979235842015 @default.
• W2097923584 countsByYear W20979235842017 @default.
• W2097923584 countsByYear W20979235842018 @default.
• W2097923584 countsByYear W20979235842019 @default.
• W2097923584 countsByYear W20979235842021 @default.
• W2097923584 countsByYear W20979235842023 @default.
• W2097923584 crossrefType "journal-article" @default.
• W2097923584 hasAuthorship W2097923584A5001462127 @default.
• W2097923584 hasAuthorship W2097923584A5011129933 @default.
• W2097923584 hasAuthorship W2097923584A5011148296 @default.
• W2097923584 hasAuthorship W2097923584A5018436834 @default.
• W2097923584 hasAuthorship W2097923584A5031475597 @default.
• W2097923584 hasAuthorship W2097923584A5040670477 @default.
• W2097923584 hasAuthorship W2097923584A5057050252 @default.
• W2097923584 hasAuthorship W2097923584A5063555195 @default.
• W2097923584 hasAuthorship W2097923584A5069964953 @default.
• W2097923584 hasAuthorship W2097923584A5074568352 @default.
• W2097923584 hasAuthorship W2097923584A5074588571 @default.
• W2097923584 hasAuthorship W2097923584A5079020015 @default.
• W2097923584 hasAuthorship W2097923584A5083104890 @default.

• next