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- W2097925847 abstract "Expired 13 CO 2 recovery from an oral l-[1- 13 C]phenylalanine ([ 13 C]Phe) dose has been used to quantify liver function. This parameter, however, does not depend solely on liver function but also on total CO 2 production, Phe turnover, and initial tracer distribution. Therefore, we evaluated the impact of these factors on breath test values. Nine ethyl-toxic cirrhotic patients and nine control subjects received intravenously 2 mg/kg of [ 13 C]Phe, and breath and blood samples were collected over 4 h. CO 2 production was measured by indirect calorimetry. The exhaled 13 CO 2 enrichments were analyzed by isotope ratio mass spectrometry and the [ 13 C]Phe and l-[1- 13 C]tyrosine enrichments by gas chromatography-mass spectrometry. The cumulative 13 CO 2 recovery was significantly lower in cirrhotic patients (7 vs. 12%; P < 0.01), in part due to lower total CO 2 production rates. Phe turnover in cirrhotic patients was significantly lower (33 vs. 44 μmol · kg −1 · h −1 ; P < 0.05). When these extrahepatic factors were considered in the calculation of the Phe oxidation rate, the intergroup differences were even more pronounced (3 vs. 7 μmol · kg −1 · h −1 ) than those for 13 CO 2 recovery data. Also, the Phe-to-Tyr conversion rate, another indicator of Phe oxidation, was significantly reduced (0.7 vs. 3.0 μmol · kg −1 · h −1 )." @default.
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- W2097925847 date "2002-12-01" @default.
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- W2097925847 title "Phenylalanine kinetics in healthy volunteers and liver cirrhotics: implications for the phenylalanine breath test" @default.
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- W2097925847 doi "https://doi.org/10.1152/ajpendo.0311.2001" @default.
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