FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097930891> ?p ?o ?g. }

• W2097930891 endingPage "2239" @default.
• W2097930891 startingPage "2231" @default.
• W2097930891 abstract "Abstract The response to respiratory syncytial virus (RSV), negative strand ssRNA virus, depends upon the ability to recognize specific pathogen-associated targets. In the current study, the role of TLR7 that recognizes ssRNA was examined. Using TLR7−/− mice, we found that the response to RSV infection in the lung was more pathogenic as assessed by significant increases in inflammation and mucus production. Although there appeared to be no effect of TLR7 deficiency on type I IFN, the pathology was associated with an alteration in T cell responses with increases in mucogenic cytokines IL-4, IL-13, and IL-17. Examination of dendritic cells from TLR7−/− animals indicated a preferential activation of IL-23 (a Th17-promoting cytokine) and a decrease in IL-12 production. Neutralization of IL-17 in the TLR7−/− mice resulted in a significant decrease in the mucogenic response in the lungs of the RSV-infected mice. Thus, without TLR7-mediated responses, an altered immune environment ensued with a significant effect on airway epithelial cell remodeling and goblet cell hyper/metaplasia, leading to increased mucus production." @default.
• W2097930891 created "2016-06-24" @default.
• W2097930891 creator A5040117830 @default.
• W2097930891 creator A5042962603 @default.
• W2097930891 creator A5044790672 @default.
• W2097930891 creator A5058759130 @default.
• W2097930891 creator A5061683904 @default.
• W2097930891 creator A5088974704 @default.
• W2097930891 date "2010-08-15" @default.
• W2097930891 modified "2023-10-17" @default.
• W2097930891 title "Respiratory Virus-Induced TLR7 Activation Controls IL-17–Associated Increased Mucus via IL-23 Regulation" @default.
• W2097930891 cites W1499978168 @default.
• W2097930891 cites W1537830090 @default.
• W2097930891 cites W1541399456 @default.
• W2097930891 cites W1577886890 @default.
• W2097930891 cites W1591790122 @default.
• W2097930891 cites W1592851115 @default.
• W2097930891 cites W1597676074 @default.
• W2097930891 cites W1606683819 @default.
• W2097930891 cites W1840746127 @default.
• W2097930891 cites W1923164049 @default.
• W2097930891 cites W1966911537 @default.
• W2097930891 cites W1967562647 @default.
• W2097930891 cites W1969971573 @default.
• W2097930891 cites W1981480267 @default.
• W2097930891 cites W1994391392 @default.
• W2097930891 cites W2008826892 @default.
• W2097930891 cites W2009219530 @default.
• W2097930891 cites W2010508808 @default.
• W2097930891 cites W2012132820 @default.
• W2097930891 cites W2015070142 @default.
• W2097930891 cites W2017218161 @default.
• W2097930891 cites W2017851594 @default.
• W2097930891 cites W2033887642 @default.
• W2097930891 cites W2039588722 @default.
• W2097930891 cites W2045384882 @default.
• W2097930891 cites W2046212128 @default.
• W2097930891 cites W2057832232 @default.
• W2097930891 cites W2058870545 @default.
• W2097930891 cites W2060616257 @default.
• W2097930891 cites W2060731298 @default.
• W2097930891 cites W2062944553 @default.
• W2097930891 cites W2066636120 @default.
• W2097930891 cites W2069157544 @default.
• W2097930891 cites W2072545085 @default.
• W2097930891 cites W2076342782 @default.
• W2097930891 cites W2080456371 @default.
• W2097930891 cites W2092325730 @default.
• W2097930891 cites W2100343814 @default.
• W2097930891 cites W2101292818 @default.
• W2097930891 cites W2101363646 @default.
• W2097930891 cites W2108356820 @default.
• W2097930891 cites W2109666345 @default.
• W2097930891 cites W2114913546 @default.
• W2097930891 cites W2128224497 @default.
• W2097930891 cites W2128364938 @default.
• W2097930891 cites W2130272079 @default.
• W2097930891 cites W2134224958 @default.
• W2097930891 cites W2134505828 @default.
• W2097930891 cites W2136490336 @default.
• W2097930891 cites W2139392338 @default.
• W2097930891 cites W2141753982 @default.
• W2097930891 cites W2143666663 @default.
• W2097930891 cites W2144217311 @default.
• W2097930891 cites W2144505818 @default.
• W2097930891 cites W2145532819 @default.
• W2097930891 cites W2145783587 @default.
• W2097930891 cites W2147021042 @default.
• W2097930891 cites W2149654975 @default.
• W2097930891 cites W2151966368 @default.
• W2097930891 cites W2157898241 @default.
• W2097930891 cites W2160883911 @default.
• W2097930891 cites W2161208630 @default.
• W2097930891 cites W2164610956 @default.
• W2097930891 cites W2166289732 @default.
• W2097930891 cites W4361866506 @default.
• W2097930891 cites W2098751820 @default.
• W2097930891 doi "https://doi.org/10.4049/jimmunol.1000733" @default.
• W2097930891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3006454" @default.
• W2097930891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20624950" @default.
• W2097930891 hasPublicationYear "2010" @default.
• W2097930891 type Work @default.
• W2097930891 sameAs 2097930891 @default.
• W2097930891 citedByCount "104" @default.
• W2097930891 countsByYear W20979308912012 @default.
• W2097930891 countsByYear W20979308912013 @default.
• W2097930891 countsByYear W20979308912014 @default.
• W2097930891 countsByYear W20979308912015 @default.
• W2097930891 countsByYear W20979308912016 @default.
• W2097930891 countsByYear W20979308912017 @default.
• W2097930891 countsByYear W20979308912018 @default.
• W2097930891 countsByYear W20979308912019 @default.
• W2097930891 countsByYear W20979308912020 @default.
• W2097930891 countsByYear W20979308912021 @default.
• W2097930891 countsByYear W20979308912022 @default.
• W2097930891 countsByYear W20979308912023 @default.
• W2097930891 crossrefType "journal-article" @default.
• W2097930891 hasAuthorship W2097930891A5040117830 @default.

• next