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• W2097933072 abstract "To determine whether the EP4 receptor for prostaglandin E 2 (PGE 2 ) contributes to the tumor promoting activity of PGs in murine skin, EP4 over‐expressing mice (BK5.EP4) were generated and subjected carcinogenesis protocols. An initiation/promotion protocol resulted in 25‐fold more squamous cell carcinomas (SCCs) in the BK5.EP4 mice than wild type (WT) mice. An increase in SCCs also occurred following treatment with initiator alone or UV irradiation. The initiator dimethylbenz[a]anthracene caused cytotoxicity in BK5.EP4, but not WT mice, characterized by sloughing of the interfollicular epidermis, regeneration and subsequent SCC development. A comparison of transcriptomes between BK5.EP4 and WT mice treated with PGE2 showed a significant upregulation of a number of genes known to be associated with tumor development, supporting a pro‐tumorigenic role for the EP4 receptor." @default.
• W2097933072 created "2016-06-24" @default.
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• W2097933072 date "2014-07-03" @default.
• W2097933072 modified "2023-10-15" @default.
• W2097933072 title "The tumor promoting activity of the EP4 receptor for prostaglandin E₂in murine skin" @default.
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• W2097933072 doi "https://doi.org/10.1016/j.molonc.2014.06.013" @default.
• W2097933072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4253556" @default.
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