Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097934619> ?p ?o ?g. }
- W2097934619 endingPage "1253" @default.
- W2097934619 startingPage "1246" @default.
- W2097934619 abstract "Human epidermal growth factor receptor 2 (HER2) overexpression increases the aggressiveness of breast cancer cells resulting in poorer prognosis. Patients with HER2-positive disease are less responsive to endocrine therapies. Trastuzumab monotherapy results in objective responses in only approximately 15% of patients. Fulvestrant retains activity in cells overexpressing HER2 that are resistant to other endocrine treatments. This retrospective study evaluated response to fulvestrant treatment among HER2-positive patients with advanced breast cancer (ABC).Clinical experience data from 10 treatment centres were pooled. Postmenopausal patients with predominantly hormone receptor-positive and HER2-positive disease were included. Clinical benefit (CB) was defined as the proportion of patients achieving a response to treatment (partial or complete) or stable disease lasting >/=6 months.Data for 102 patients were analysed. Fulvestrant resulted in an overall CB rate of 42% (43/101) in HER2-positive patients and 40% (25/63) in patients with visceral disease. Median duration of treatment was 14.5 months (range 6-44 months). Fulvestrant showed activity up to the fourth line of endocrine therapy and up to the seventh line of overall therapy.Results indicate that fulvestrant may be a suitable treatment option in extensively pre-treated patients with HER2-positive, hormone receptor-positive ABC. Further exploration of its use in this patient population is warranted." @default.
- W2097934619 created "2016-06-24" @default.
- W2097934619 creator A5000705184 @default.
- W2097934619 creator A5007579054 @default.
- W2097934619 creator A5036695602 @default.
- W2097934619 creator A5039135644 @default.
- W2097934619 creator A5047049476 @default.
- W2097934619 creator A5049907389 @default.
- W2097934619 creator A5050390557 @default.
- W2097934619 creator A5053689364 @default.
- W2097934619 creator A5061179981 @default.
- W2097934619 creator A5073889721 @default.
- W2097934619 creator A5084629809 @default.
- W2097934619 date "2010-06-01" @default.
- W2097934619 modified "2023-10-18" @default.
- W2097934619 title "Activity of fulvestrant in HER2-overexpressing advanced breast cancer" @default.
- W2097934619 cites W1898692666 @default.
- W2097934619 cites W1961026612 @default.
- W2097934619 cites W1977221327 @default.
- W2097934619 cites W1989039321 @default.
- W2097934619 cites W2009983407 @default.
- W2097934619 cites W2024614936 @default.
- W2097934619 cites W2024654932 @default.
- W2097934619 cites W2041122696 @default.
- W2097934619 cites W2049579456 @default.
- W2097934619 cites W2051450023 @default.
- W2097934619 cites W2062073156 @default.
- W2097934619 cites W2062713892 @default.
- W2097934619 cites W2065118889 @default.
- W2097934619 cites W2073104464 @default.
- W2097934619 cites W2077266258 @default.
- W2097934619 cites W2080403652 @default.
- W2097934619 cites W2102620699 @default.
- W2097934619 cites W2106181427 @default.
- W2097934619 cites W2125713798 @default.
- W2097934619 cites W2131475305 @default.
- W2097934619 cites W2132180344 @default.
- W2097934619 cites W2140064604 @default.
- W2097934619 cites W2141647078 @default.
- W2097934619 cites W2148320836 @default.
- W2097934619 cites W2149711808 @default.
- W2097934619 cites W2150231693 @default.
- W2097934619 cites W2158600871 @default.
- W2097934619 cites W2159459001 @default.
- W2097934619 cites W2163254077 @default.
- W2097934619 cites W2163655381 @default.
- W2097934619 cites W2166958743 @default.
- W2097934619 cites W2170976149 @default.
- W2097934619 cites W2171260495 @default.
- W2097934619 cites W2221516177 @default.
- W2097934619 cites W2730858185 @default.
- W2097934619 cites W3148607889 @default.
- W2097934619 doi "https://doi.org/10.1093/annonc/mdp447" @default.
- W2097934619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19875750" @default.
- W2097934619 hasPublicationYear "2010" @default.
- W2097934619 type Work @default.
- W2097934619 sameAs 2097934619 @default.
- W2097934619 citedByCount "21" @default.
- W2097934619 countsByYear W20979346192012 @default.
- W2097934619 countsByYear W20979346192013 @default.
- W2097934619 countsByYear W20979346192014 @default.
- W2097934619 countsByYear W20979346192015 @default.
- W2097934619 countsByYear W20979346192017 @default.
- W2097934619 countsByYear W20979346192018 @default.
- W2097934619 countsByYear W20979346192021 @default.
- W2097934619 countsByYear W20979346192022 @default.
- W2097934619 countsByYear W20979346192023 @default.
- W2097934619 crossrefType "journal-article" @default.
- W2097934619 hasAuthorship W2097934619A5000705184 @default.
- W2097934619 hasAuthorship W2097934619A5007579054 @default.
- W2097934619 hasAuthorship W2097934619A5036695602 @default.
- W2097934619 hasAuthorship W2097934619A5039135644 @default.
- W2097934619 hasAuthorship W2097934619A5047049476 @default.
- W2097934619 hasAuthorship W2097934619A5049907389 @default.
- W2097934619 hasAuthorship W2097934619A5050390557 @default.
- W2097934619 hasAuthorship W2097934619A5053689364 @default.
- W2097934619 hasAuthorship W2097934619A5061179981 @default.
- W2097934619 hasAuthorship W2097934619A5073889721 @default.
- W2097934619 hasAuthorship W2097934619A5084629809 @default.
- W2097934619 hasBestOaLocation W20979346191 @default.
- W2097934619 hasConcept C121608353 @default.
- W2097934619 hasConcept C126322002 @default.
- W2097934619 hasConcept C143998085 @default.
- W2097934619 hasConcept C23589133 @default.
- W2097934619 hasConcept C2775930923 @default.
- W2097934619 hasConcept C2777176818 @default.
- W2097934619 hasConcept C2779786085 @default.
- W2097934619 hasConcept C2780482068 @default.
- W2097934619 hasConcept C2908647359 @default.
- W2097934619 hasConcept C29456083 @default.
- W2097934619 hasConcept C46699223 @default.
- W2097934619 hasConcept C530470458 @default.
- W2097934619 hasConcept C71315377 @default.
- W2097934619 hasConcept C71924100 @default.
- W2097934619 hasConcept C99454951 @default.
- W2097934619 hasConceptScore W2097934619C121608353 @default.
- W2097934619 hasConceptScore W2097934619C126322002 @default.
- W2097934619 hasConceptScore W2097934619C143998085 @default.