FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097937570> ?p ?o ?g. }

• W2097937570 endingPage "447" @default.
• W2097937570 startingPage "429" @default.
• W2097937570 abstract "K(m) and V(max) values for 10 coenzyme analogs never previously studied with any aldehyde dehydrogenase and NADP(+) were compared with those for NAD(+) for three human aldehyde dehydrogenases (EC 1.2.1.3); the cytoplasmic E1 (the product of the aldh1 gene), the mitochondrial E2 (the product of the aldh2 gene) and the cytoplasmic E3 (the product of the aldh9 gene) isozymes. Structural information on changes in coenzyme-protein interactions were obtained via molecular dynamics (MD) studies with the E2 isozyme and quantum mechanical (QM) calculations were used to study changes in charge distribution of the pyridine ring and relative free energies of solvation of the purine ring in the analogs. E1 showed the broadest substrate specificity and was the only isozyme subject to substrate inhibition, both of which are suggested to be due to the two coenzyme conformations observed previously in the sheep crystal structure. NADP(+) selectivity is indicated to be influenced by Glu195 in E1 and E2. Substitutions in the purine ring affected K(m) but not V(max), with the changes in K(m) being dominated by the hydrophobicity of the purine ring as indicted by the QM calculations. Substitutions in the pyridine ring sometimes rendered the coenzymes inactive, with no consistent pattern observed for the three coenzymes. Structural analysis of the coenzyme analog-E2 MD simulations revealed different structural perturbations of the surrounding active site, though interactions with Asn169 and Glu399 were preserved in all cases." @default.
• W2097937570 created "2016-06-24" @default.
• W2097937570 creator A5001435633 @default.
• W2097937570 creator A5005548997 @default.
• W2097937570 creator A5074023456 @default.
• W2097937570 creator A5088006458 @default.
• W2097937570 date "2001-12-01" @default.
• W2097937570 modified "2023-09-28" @default.
• W2097937570 title "Human Aldehyde Dehydrogenase Catalytic Activity and Structural Interactions with Coenzyme Analogs" @default.
• W2097937570 cites W127102381 @default.
• W2097937570 cites W149735186 @default.
• W2097937570 cites W1513494328 @default.
• W2097937570 cites W1522260392 @default.
• W2097937570 cites W1571689153 @default.
• W2097937570 cites W1579417853 @default.
• W2097937570 cites W164965000 @default.
• W2097937570 cites W176176938 @default.
• W2097937570 cites W1854024296 @default.
• W2097937570 cites W1965158345 @default.
• W2097937570 cites W1967534276 @default.
• W2097937570 cites W1968105649 @default.
• W2097937570 cites W1973876874 @default.
• W2097937570 cites W1975480828 @default.
• W2097937570 cites W1978109629 @default.
• W2097937570 cites W1979243197 @default.
• W2097937570 cites W1980409558 @default.
• W2097937570 cites W1981324511 @default.
• W2097937570 cites W1984599229 @default.
• W2097937570 cites W1987702006 @default.
• W2097937570 cites W2002722345 @default.
• W2097937570 cites W2003894482 @default.
• W2097937570 cites W2007648952 @default.
• W2097937570 cites W2012874841 @default.
• W2097937570 cites W2014485682 @default.
• W2097937570 cites W2019616898 @default.
• W2097937570 cites W2024225780 @default.
• W2097937570 cites W2028140643 @default.
• W2097937570 cites W2029867653 @default.
• W2097937570 cites W2034647911 @default.
• W2097937570 cites W2038121498 @default.
• W2097937570 cites W2042156008 @default.
• W2097937570 cites W2042968221 @default.
• W2097937570 cites W2054289914 @default.
• W2097937570 cites W2054979333 @default.
• W2097937570 cites W2059890422 @default.
• W2097937570 cites W2069099296 @default.
• W2097937570 cites W2072587096 @default.
• W2097937570 cites W2077657779 @default.
• W2097937570 cites W2079905273 @default.
• W2097937570 cites W2079938883 @default.
• W2097937570 cites W2081718721 @default.
• W2097937570 cites W2084352099 @default.
• W2097937570 cites W2085629085 @default.
• W2097937570 cites W2106140689 @default.
• W2097937570 cites W2120488115 @default.
• W2097937570 cites W2138392605 @default.
• W2097937570 cites W2147421370 @default.
• W2097937570 cites W2162166182 @default.
• W2097937570 cites W24909239 @default.
• W2097937570 cites W2969273703 @default.
• W2097937570 cites W4076929 @default.
• W2097937570 cites W50126086 @default.
• W2097937570 cites W614018474 @default.
• W2097937570 cites W87354709 @default.
• W2097937570 doi "https://doi.org/10.1080/07391102.2001.10506752" @default.
• W2097937570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11790142" @default.
• W2097937570 hasPublicationYear "2001" @default.
• W2097937570 type Work @default.
• W2097937570 sameAs 2097937570 @default.
• W2097937570 citedByCount "5" @default.
• W2097937570 countsByYear W20979375702013 @default.
• W2097937570 countsByYear W20979375702016 @default.
• W2097937570 countsByYear W20979375702017 @default.
• W2097937570 countsByYear W20979375702018 @default.
• W2097937570 crossrefType "journal-article" @default.
• W2097937570 hasAuthorship W2097937570A5001435633 @default.
• W2097937570 hasAuthorship W2097937570A5005548997 @default.
• W2097937570 hasAuthorship W2097937570A5074023456 @default.
• W2097937570 hasAuthorship W2097937570A5088006458 @default.
• W2097937570 hasConcept C119795356 @default.
• W2097937570 hasConcept C181199279 @default.
• W2097937570 hasConcept C185592680 @default.
• W2097937570 hasConcept C197957613 @default.
• W2097937570 hasConcept C41183919 @default.
• W2097937570 hasConcept C55493867 @default.
• W2097937570 hasConcept C71240020 @default.
• W2097937570 hasConcept C75520062 @default.
• W2097937570 hasConceptScore W2097937570C119795356 @default.
• W2097937570 hasConceptScore W2097937570C181199279 @default.
• W2097937570 hasConceptScore W2097937570C185592680 @default.
• W2097937570 hasConceptScore W2097937570C197957613 @default.
• W2097937570 hasConceptScore W2097937570C41183919 @default.
• W2097937570 hasConceptScore W2097937570C55493867 @default.
• W2097937570 hasConceptScore W2097937570C71240020 @default.
• W2097937570 hasConceptScore W2097937570C75520062 @default.
• W2097937570 hasIssue "3" @default.
• W2097937570 hasLocation W20979375701 @default.
• W2097937570 hasLocation W20979375702 @default.

• next