Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097961105> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2097961105 endingPage "2962" @default.
- W2097961105 startingPage "2957" @default.
- W2097961105 abstract "Background: Palladin is a metastasis-associated gene regulating cell motility. The expression of palladin protein in pancreatic neuroendocrine tumors (PET) and carcinomas (PECA) is not known. Materials and Methods: A tissue microarray (TMA) of well-differentiated (WD) PETs/PECAs (AJCC 2010) and non-neoplastic, histologically normal pancreatic tissue/islets (HNPIs) was immunostained with palladin antibody and quantified using the Allred score. The results were correlated with the presence or absence of liver metastases. Results: The retrospective study included 19 males and 19 females of age 27-79 years (mean 54). Tumor size was 0.9-11.5 cm (mean 3.8). Palladin expression was cytoplasmic and/or membranous. The tumors with high palladin expression were associated with liver metastasis (p<0.0001). All 14 primary PECA with hepatic metastases (MP-PECAs) exhibited palladin expression whereas 14 out of 24 (58%) clinically- localized primary PET (CLP-PETs) expressed palladin (p<0.01) with median Allred scores of 5 (range 3-7) and 2 (range 0-6) respectively (p<0.0001). The mean Allred score for the HNPIs in the MP-PECAs (N=6) was higher (4.2) as compared to that in the CLP-PETs (2.5,N=11) (p=0.23). Conclusion: Palladin may identify primary pancreatic endocrine neoplasms with a propensity to metastasize to the liver. Pancreatic neuroendocrine tumors/carcinomas (PETs/ PECAs) account for 1-2% of pancreatic neoplasms and are clinically challenging (1). The clinical behavior of PET is often unpredictable. According to the current American Joint Committee on Cancer (AJCC) Staging manual (2), well- differentiated (WD) PECAs (WD-PECAs) are separated from well-differentiated PETs (WD-PETs) on the basis of gross invasion of the adjacent organs by the tumor (duodenum, stomach, spleen) and/or the presence of metastases. With the development of metastases, patient survival significantly drops and none of the currently available therapies offer cure. The discovery of molecular markers of metastases would offer newer objective criteria to determine patient prognosis and may improve our" @default.
- W2097961105 created "2016-06-24" @default.
- W2097961105 creator A5007326037 @default.
- W2097961105 creator A5053957826 @default.
- W2097961105 creator A5066913959 @default.
- W2097961105 creator A5068503288 @default.
- W2097961105 creator A5070939257 @default.
- W2097961105 creator A5076324164 @default.
- W2097961105 creator A5082120823 @default.
- W2097961105 creator A5089225736 @default.
- W2097961105 date "2011-09-01" @default.
- W2097961105 modified "2023-09-23" @default.
- W2097961105 title "Palladin is a Marker of Liver Metastasis in Primary Pancreatic Endocrine Carcinomas" @default.
- W2097961105 cites W1968929155 @default.
- W2097961105 cites W1978718921 @default.
- W2097961105 cites W1984093978 @default.
- W2097961105 cites W2015695457 @default.
- W2097961105 cites W2029445630 @default.
- W2097961105 cites W2035990123 @default.
- W2097961105 cites W2038382085 @default.
- W2097961105 cites W2048914779 @default.
- W2097961105 cites W2078801475 @default.
- W2097961105 cites W2101002731 @default.
- W2097961105 cites W2101817871 @default.
- W2097961105 cites W2110068146 @default.
- W2097961105 cites W2117539984 @default.
- W2097961105 cites W2140347429 @default.
- W2097961105 cites W2146864292 @default.
- W2097961105 cites W2327643100 @default.
- W2097961105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21868544" @default.
- W2097961105 hasPublicationYear "2011" @default.
- W2097961105 type Work @default.
- W2097961105 sameAs 2097961105 @default.
- W2097961105 citedByCount "3" @default.
- W2097961105 countsByYear W20979611052016 @default.
- W2097961105 countsByYear W20979611052017 @default.
- W2097961105 countsByYear W20979611052021 @default.
- W2097961105 crossrefType "journal-article" @default.
- W2097961105 hasAuthorship W2097961105A5007326037 @default.
- W2097961105 hasAuthorship W2097961105A5053957826 @default.
- W2097961105 hasAuthorship W2097961105A5066913959 @default.
- W2097961105 hasAuthorship W2097961105A5068503288 @default.
- W2097961105 hasAuthorship W2097961105A5070939257 @default.
- W2097961105 hasAuthorship W2097961105A5076324164 @default.
- W2097961105 hasAuthorship W2097961105A5082120823 @default.
- W2097961105 hasAuthorship W2097961105A5089225736 @default.
- W2097961105 hasConcept C121608353 @default.
- W2097961105 hasConcept C126322002 @default.
- W2097961105 hasConcept C142724271 @default.
- W2097961105 hasConcept C2778764654 @default.
- W2097961105 hasConcept C2779013556 @default.
- W2097961105 hasConcept C2780210213 @default.
- W2097961105 hasConcept C46699223 @default.
- W2097961105 hasConcept C71315377 @default.
- W2097961105 hasConcept C71924100 @default.
- W2097961105 hasConceptScore W2097961105C121608353 @default.
- W2097961105 hasConceptScore W2097961105C126322002 @default.
- W2097961105 hasConceptScore W2097961105C142724271 @default.
- W2097961105 hasConceptScore W2097961105C2778764654 @default.
- W2097961105 hasConceptScore W2097961105C2779013556 @default.
- W2097961105 hasConceptScore W2097961105C2780210213 @default.
- W2097961105 hasConceptScore W2097961105C46699223 @default.
- W2097961105 hasConceptScore W2097961105C71315377 @default.
- W2097961105 hasConceptScore W2097961105C71924100 @default.
- W2097961105 hasIssue "9" @default.
- W2097961105 hasLocation W20979611051 @default.
- W2097961105 hasOpenAccess W2097961105 @default.
- W2097961105 hasPrimaryLocation W20979611051 @default.
- W2097961105 hasRelatedWork W1989409003 @default.
- W2097961105 hasRelatedWork W1995308143 @default.
- W2097961105 hasRelatedWork W2018314777 @default.
- W2097961105 hasRelatedWork W2028786127 @default.
- W2097961105 hasRelatedWork W2037231321 @default.
- W2097961105 hasRelatedWork W2040186124 @default.
- W2097961105 hasRelatedWork W2042674375 @default.
- W2097961105 hasRelatedWork W2045685008 @default.
- W2097961105 hasRelatedWork W2057554911 @default.
- W2097961105 hasRelatedWork W2066908088 @default.
- W2097961105 hasRelatedWork W2067697182 @default.
- W2097961105 hasRelatedWork W2075904243 @default.
- W2097961105 hasRelatedWork W2119669402 @default.
- W2097961105 hasRelatedWork W2152181867 @default.
- W2097961105 hasRelatedWork W2238874802 @default.
- W2097961105 hasRelatedWork W2312677968 @default.
- W2097961105 hasRelatedWork W2357876121 @default.
- W2097961105 hasRelatedWork W3012428894 @default.
- W2097961105 hasRelatedWork W3159544527 @default.
- W2097961105 hasRelatedWork W3204392886 @default.
- W2097961105 hasVolume "31" @default.
- W2097961105 isParatext "false" @default.
- W2097961105 isRetracted "false" @default.
- W2097961105 magId "2097961105" @default.
- W2097961105 workType "article" @default.