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- W2097984332 endingPage "1440" @default.
- W2097984332 startingPage "1433" @default.
- W2097984332 abstract "Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which use nicotinamide adenine dinucleotide (NAD + ) as a substrate to synthesize and transfer ADP-ribose units to acceptor proteins. The PARP family members possess a variety of structural domains, span a wide range of functions and localize to various cellular compartments. Among the molecular actions attributed to PARPs, their role in the DNA damage response (DDR) has been widely documented. In particular, PARPs 1–3 are involved in several cellular processes that respond to DNA lesions, which include DNA damage recognition, signaling and repair as well as local transcriptional blockage, chromatin remodeling and cell death induction. However, how these enzymes are able to participate in such numerous and diverse mechanisms in response to DNA damage is not fully understood. Herein, the DDR functions of PARPs 1–3 and the emerging roles of poly (ADP ribose) polymers in DNA damage are reviewed. The development of PARP inhibitors, their applications and mechanisms of action are also discussed in the context of the DDR." @default.
- W2097984332 created "2016-06-24" @default.
- W2097984332 creator A5008599563 @default.
- W2097984332 creator A5023967626 @default.
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- W2097984332 creator A5026643846 @default.
- W2097984332 creator A5056598316 @default.
- W2097984332 creator A5071557458 @default.
- W2097984332 creator A5079893405 @default.
- W2097984332 date "2012-03-19" @default.
- W2097984332 modified "2023-09-24" @default.
- W2097984332 title "PARPs and the DNA damage response" @default.
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