FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097984652> ?p ?o ?g. }

• W2097984652 endingPage "1044" @default.
• W2097984652 startingPage "1038" @default.
• W2097984652 abstract "Ceftazidime and meropenem are frequently used in the empirical treatment of hospital-acquired cerebrospinal fluid (CSF) infections. Although their dispositions in CSF have been described, the ability of these agents to achieve critical pharmacodynamic targets against the array of nosocomial CSF Gram-negative bacteria encountered in practice has not been reported.Serum and CSF pharmacokinetic data were obtained from hospital patients with external ventricular drains and who received ceftazidime or meropenem. Concentration-time profiles in serum and CSF were modelled using a three-compartment model with zero-order infusion and first-order elimination and transfer. The model parameters were identified using population pharmacokinetic analysis [Big Non-Parametric Adaptive Grid (BigNPAG)]. A Monte Carlo simulation (9999 subjects) estimated the probability of target attainment (PTA) for total drug CSF concentrations at 50% and 100% T(>MIC) for ceftazidime 2 g intravenously every 8 h and meropenem 2 g intravenously every 8 h. The Gram-negative infection isolates of the seven most prevalent Gram-negative bacilli from the Meropenem Yearly Susceptibility Test Information Collection Program were used as a measure of contemporary MIC distribution.Post-Bayesian measures of bias and precision, observed-predicted plots and R(2) values were highly acceptable for both drugs. Although the PTA in CSF was approximately one dilution higher for ceftazidime compared with meropenem at a given MIC value, the cumulative fraction of response (CFR) in CSF against all Gram-negatives was markedly higher for meropenem when compared with ceftazidime secondary to the higher occurrence of lower MIC values for meropenem. Both agents had a low CFR against Pseudomonas aeruginosa.The pharmacodynamics of meropenem was superior to that of ceftazidime against Gram-negative pathogens in the CSF." @default.
• W2097984652 created "2016-06-24" @default.
• W2097984652 creator A5018604997 @default.
• W2097984652 creator A5036512885 @default.
• W2097984652 creator A5044679653 @default.
• W2097984652 creator A5051117448 @default.
• W2097984652 creator A5065255082 @default.
• W2097984652 creator A5084249121 @default.
• W2097984652 date "2007-09-17" @default.
• W2097984652 modified "2023-09-26" @default.
• W2097984652 title "Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation" @default.
• W2097984652 cites W1641535649 @default.
• W2097984652 cites W1933616536 @default.
• W2097984652 cites W1965126158 @default.
• W2097984652 cites W1969507884 @default.
• W2097984652 cites W1978593990 @default.
• W2097984652 cites W1979305647 @default.
• W2097984652 cites W1991927622 @default.
• W2097984652 cites W1994993302 @default.
• W2097984652 cites W2007503737 @default.
• W2097984652 cites W2031376837 @default.
• W2097984652 cites W2038011835 @default.
• W2097984652 cites W2038300217 @default.
• W2097984652 cites W2047469610 @default.
• W2097984652 cites W2060563399 @default.
• W2097984652 cites W2062210011 @default.
• W2097984652 cites W2062495428 @default.
• W2097984652 cites W2064285851 @default.
• W2097984652 cites W2067034394 @default.
• W2097984652 cites W2079691262 @default.
• W2097984652 cites W2087947497 @default.
• W2097984652 cites W2096014092 @default.
• W2097984652 cites W2106692990 @default.
• W2097984652 cites W2106868673 @default.
• W2097984652 cites W2113089307 @default.
• W2097984652 cites W2113717321 @default.
• W2097984652 cites W2122314338 @default.
• W2097984652 cites W2124722642 @default.
• W2097984652 cites W2127182132 @default.
• W2097984652 cites W2136725579 @default.
• W2097984652 cites W2139805356 @default.
• W2097984652 cites W2159994038 @default.
• W2097984652 cites W2169457750 @default.
• W2097984652 cites W2169480625 @default.
• W2097984652 cites W2171559883 @default.
• W2097984652 cites W2171732900 @default.
• W2097984652 cites W2334914963 @default.
• W2097984652 cites W2407236185 @default.
• W2097984652 doi "https://doi.org/10.1093/jac/dkm325" @default.
• W2097984652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17785282" @default.
• W2097984652 hasPublicationYear "2007" @default.
• W2097984652 type Work @default.
• W2097984652 sameAs 2097984652 @default.
• W2097984652 citedByCount "46" @default.
• W2097984652 countsByYear W20979846522012 @default.
• W2097984652 countsByYear W20979846522013 @default.
• W2097984652 countsByYear W20979846522014 @default.
• W2097984652 countsByYear W20979846522015 @default.
• W2097984652 countsByYear W20979846522016 @default.
• W2097984652 countsByYear W20979846522017 @default.
• W2097984652 countsByYear W20979846522018 @default.
• W2097984652 countsByYear W20979846522019 @default.
• W2097984652 countsByYear W20979846522020 @default.
• W2097984652 countsByYear W20979846522021 @default.
• W2097984652 countsByYear W20979846522022 @default.
• W2097984652 crossrefType "journal-article" @default.
• W2097984652 hasAuthorship W2097984652A5018604997 @default.
• W2097984652 hasAuthorship W2097984652A5036512885 @default.
• W2097984652 hasAuthorship W2097984652A5044679653 @default.
• W2097984652 hasAuthorship W2097984652A5051117448 @default.
• W2097984652 hasAuthorship W2097984652A5065255082 @default.
• W2097984652 hasAuthorship W2097984652A5084249121 @default.
• W2097984652 hasBestOaLocation W20979846521 @default.
• W2097984652 hasConcept C111113717 @default.
• W2097984652 hasConcept C112705442 @default.
• W2097984652 hasConcept C126322002 @default.
• W2097984652 hasConcept C176947019 @default.
• W2097984652 hasConcept C2776968632 @default.
• W2097984652 hasConcept C2777637488 @default.
• W2097984652 hasConcept C2779375183 @default.
• W2097984652 hasConcept C2908647359 @default.
• W2097984652 hasConcept C3019249092 @default.
• W2097984652 hasConcept C501593827 @default.
• W2097984652 hasConcept C523546767 @default.
• W2097984652 hasConcept C54355233 @default.
• W2097984652 hasConcept C71924100 @default.
• W2097984652 hasConcept C86803240 @default.
• W2097984652 hasConcept C89423630 @default.
• W2097984652 hasConcept C94665300 @default.
• W2097984652 hasConcept C98274493 @default.
• W2097984652 hasConcept C99454951 @default.
• W2097984652 hasConceptScore W2097984652C111113717 @default.
• W2097984652 hasConceptScore W2097984652C112705442 @default.
• W2097984652 hasConceptScore W2097984652C126322002 @default.
• W2097984652 hasConceptScore W2097984652C176947019 @default.
• W2097984652 hasConceptScore W2097984652C2776968632 @default.
• W2097984652 hasConceptScore W2097984652C2777637488 @default.
• W2097984652 hasConceptScore W2097984652C2779375183 @default.

• next