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• W2097989455 endingPage "1328" @default.
• W2097989455 startingPage "1319" @default.
• W2097989455 abstract "The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls. Ligand binding leads to dimerization of the AhR with aryl hydrocarbon receptor nuclear translocator and transcriptional activation of several xenobiotic phase I and phase II metabolizing enzymes, such as cytochrome P4501A1 and glutathione- S -transferase, respectively. Since phase I enzymes convert inert carcinogens to active genotoxins, the AhR plays a key role in tumor initiation. Besides this classical route, the AhR mediates tumor promotion and recent evidence suggests that the AhR also plays a role in tumor progression. To date, no mechanistic link could be established between the canonical pathway involving xenobiotic metabolism and AhR-dependent tumor promotion and progression. A hallmark of tumor promotion is unbalanced proliferation, whereas tumor progression is characterized by dedifferentiation, increased motility and metastasis of tumor cells. Tumor progression and presumably also tumor promotion are triggered by loss of cell–cell contact. Cell–cell contact is known to be a critical regulator of proliferation, differentiation and cell motility in vitro and in vivo . Increasing evidence suggests that activation of the AhR may lead to deregulation of cell–cell contact, thereby inducing unbalanced proliferation, dedifferentiation and enhanced motility. In line with this is the finding of increased AhR expression and malignancy in some animal and human cancers. Here, we summarize our current knowledge on non-canonical AhR-driven pathways being involved in deregulation of cell–cell contact and discuss the data with respect to tumor initiation, promotion and progression." @default.
• W2097989455 created "2016-06-24" @default.
• W2097989455 creator A5026593378 @default.
• W2097989455 creator A5069802873 @default.
• W2097989455 date "2010-01-27" @default.
• W2097989455 modified "2023-10-17" @default.
• W2097989455 title "The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth" @default.
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