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- W2097992551 abstract "Pneumocystis cariniiis an opportunistic pathogen that causes pneumonia in immunocompromised patients. To investigate the genetic diversity of P. carinii populations, multilocus enzyme electrophoresis was used to analyze five enzyme systems(malate dehydrogenase, glucose phosphate isomerase, leucine aminopeptidase, malic enzyme, and 6-phosphogluconate dehydrogenase).Only five different multilocus associations (zymodemes) were recorded for the 70 isolates studied. While only one multilocus combination was found in mice and rabbits, three different multilocus associations were recorded in rats. Population genetic tests and phylogenetic analysis strongly suggest that P. carinii genotypesare host-specific, in agreement with molecular study results, and that no genetic exchange occurs between genotypes from different host species. This hypothesis could be verified only by the evolutionary genetic approach, which relies here on multilocus analysis." @default.
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- W2097992551 date "1997-03-01" @default.
- W2097992551 modified "2023-09-26" @default.
- W2097992551 title "Isoenzyme Diversity in Pneumocystis carinii from Rats, Mice, and Rabbits" @default.
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- W2097992551 doi "https://doi.org/10.1093/infdis/175.3.655" @default.
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