Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098013749> ?p ?o ?g. }
- W2098013749 endingPage "911" @default.
- W2098013749 startingPage "904" @default.
- W2098013749 abstract "The long-term efficacy of somatostatin analogues on insulinomas has not been studied.A prospective study to evaluate the response of octreotide in 21 patients with hypoglycaemia related to endogenous hyperinsulinism who were not treated by surgery.Reasons for not undergoing surgery were: refusal (n = 3), old age with multiple diseases (n = 5), unlocalized insulinomas (n = 2), malignant unresectable insulinomas (n = 5), multiple insulinomas (n = 3) and diffuse beta-cell disease (n = 3). Hypoglycaemia was responsive to octreotide in 14 of the 21 patients. A short 100-microg octreotide test correctly predicted the efficacy of treatment in six patients with benign insulinomas. Octreoscan scintigraphy was positive in 6 of the 16 patients of whom three were responsive and three unresponsive to octreotide. Octreoscan scintigraphy was negative in 10 of the 16 patients, eight of whom were responsive to octreotide. Subcutaneous octreotide treatment was prolonged for > 6 months (7-144 months, 67 +/- 47 months) in 11 responsive patients. No tachyphylaxis was observed. However, the octreotide dose had to be increased in two patients after 3 and 18 months, respectively. Only one patient suffered from symptomatic biliary lithiasis after 3 years of treatment.Long-term octreotide treatment can be used to control hypoglycaemia in patients with endogenous hyperinsulinism who are not eligible for surgery; octreotide efficacy on hypoglycaemia could be predicted by a short 100 microg-octreotide test in patients with benign insulinomas, but was not correctly predicted by Octreoscan scintigraphy." @default.
- W2098013749 created "2016-06-24" @default.
- W2098013749 creator A5000683176 @default.
- W2098013749 creator A5000908628 @default.
- W2098013749 creator A5009623017 @default.
- W2098013749 creator A5049248014 @default.
- W2098013749 date "2008-06-01" @default.
- W2098013749 modified "2023-09-27" @default.
- W2098013749 title "Short- and long-term somatostatin analogue treatment in patients with hypoglycaemia related to endogenous hyperinsulinism" @default.
- W2098013749 cites W1975789485 @default.
- W2098013749 cites W1977347411 @default.
- W2098013749 cites W1993733299 @default.
- W2098013749 cites W1999066384 @default.
- W2098013749 cites W2005674134 @default.
- W2098013749 cites W2013373088 @default.
- W2098013749 cites W2022255159 @default.
- W2098013749 cites W2026910892 @default.
- W2098013749 cites W2033641830 @default.
- W2098013749 cites W2038843944 @default.
- W2098013749 cites W2040937520 @default.
- W2098013749 cites W2041357642 @default.
- W2098013749 cites W2042308572 @default.
- W2098013749 cites W2045662590 @default.
- W2098013749 cites W2046416579 @default.
- W2098013749 cites W2048306227 @default.
- W2098013749 cites W2055553033 @default.
- W2098013749 cites W2068892769 @default.
- W2098013749 cites W2071417408 @default.
- W2098013749 cites W2077227793 @default.
- W2098013749 cites W2091875973 @default.
- W2098013749 cites W2093743529 @default.
- W2098013749 cites W2103007177 @default.
- W2098013749 cites W2118631824 @default.
- W2098013749 cites W2143517945 @default.
- W2098013749 cites W2152643899 @default.
- W2098013749 cites W2153632959 @default.
- W2098013749 cites W2157599679 @default.
- W2098013749 cites W2164334020 @default.
- W2098013749 cites W4239331730 @default.
- W2098013749 cites W4243181481 @default.
- W2098013749 cites W4251110911 @default.
- W2098013749 doi "https://doi.org/10.1111/j.1365-2265.2007.03136.x" @default.
- W2098013749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18031316" @default.
- W2098013749 hasPublicationYear "2008" @default.
- W2098013749 type Work @default.
- W2098013749 sameAs 2098013749 @default.
- W2098013749 citedByCount "45" @default.
- W2098013749 countsByYear W20980137492012 @default.
- W2098013749 countsByYear W20980137492013 @default.
- W2098013749 countsByYear W20980137492014 @default.
- W2098013749 countsByYear W20980137492015 @default.
- W2098013749 countsByYear W20980137492016 @default.
- W2098013749 countsByYear W20980137492017 @default.
- W2098013749 countsByYear W20980137492018 @default.
- W2098013749 countsByYear W20980137492019 @default.
- W2098013749 countsByYear W20980137492020 @default.
- W2098013749 countsByYear W20980137492021 @default.
- W2098013749 countsByYear W20980137492022 @default.
- W2098013749 countsByYear W20980137492023 @default.
- W2098013749 crossrefType "journal-article" @default.
- W2098013749 hasAuthorship W2098013749A5000683176 @default.
- W2098013749 hasAuthorship W2098013749A5000908628 @default.
- W2098013749 hasAuthorship W2098013749A5009623017 @default.
- W2098013749 hasAuthorship W2098013749A5049248014 @default.
- W2098013749 hasConcept C126322002 @default.
- W2098013749 hasConcept C134018914 @default.
- W2098013749 hasConcept C168481208 @default.
- W2098013749 hasConcept C2776297358 @default.
- W2098013749 hasConcept C2777368190 @default.
- W2098013749 hasConcept C2777391703 @default.
- W2098013749 hasConcept C2777643638 @default.
- W2098013749 hasConcept C2778764654 @default.
- W2098013749 hasConcept C2779306644 @default.
- W2098013749 hasConcept C2779902710 @default.
- W2098013749 hasConcept C2780053029 @default.
- W2098013749 hasConcept C2780668416 @default.
- W2098013749 hasConcept C2781025020 @default.
- W2098013749 hasConcept C71924100 @default.
- W2098013749 hasConcept C90924648 @default.
- W2098013749 hasConceptScore W2098013749C126322002 @default.
- W2098013749 hasConceptScore W2098013749C134018914 @default.
- W2098013749 hasConceptScore W2098013749C168481208 @default.
- W2098013749 hasConceptScore W2098013749C2776297358 @default.
- W2098013749 hasConceptScore W2098013749C2777368190 @default.
- W2098013749 hasConceptScore W2098013749C2777391703 @default.
- W2098013749 hasConceptScore W2098013749C2777643638 @default.
- W2098013749 hasConceptScore W2098013749C2778764654 @default.
- W2098013749 hasConceptScore W2098013749C2779306644 @default.
- W2098013749 hasConceptScore W2098013749C2779902710 @default.
- W2098013749 hasConceptScore W2098013749C2780053029 @default.
- W2098013749 hasConceptScore W2098013749C2780668416 @default.
- W2098013749 hasConceptScore W2098013749C2781025020 @default.
- W2098013749 hasConceptScore W2098013749C71924100 @default.
- W2098013749 hasConceptScore W2098013749C90924648 @default.
- W2098013749 hasIssue "6" @default.
- W2098013749 hasLocation W20980137491 @default.
- W2098013749 hasLocation W20980137492 @default.
- W2098013749 hasOpenAccess W2098013749 @default.