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• W2098018211 endingPage "455" @default.
• W2098018211 startingPage "449" @default.
• W2098018211 abstract "In the Nonobese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes, the pathogenic process is classically thought to start at 3-4 weeks of age with an accumulation of antigen-presenting cells (APC), especially CD11c+ dendritic cells (DC), around the pancreatic islets of Langerhans. Concomitantly, hyperinsulinemia and slight hyperglucagonemia are observed, which may be either the cause or consequence of the initial APC infiltration. To determine whether infiltrating DC can affect islet activity in control (C57BL/6) and NOD mice, we performed experiments in which islets and DC were isolated and co-cultured. We first showed that, immediately after isolation, islets from 8-week-old prediabetic NOD mice had significantly higher insulin and glucagon contents than those from C57BL/6 controls. Moreover, as is the case in vivo, prediabetic NOD mouse islets secrete more insulin in vitro at 11.1 mM glucose than C57BL/6 ones. In DC-islet co-cultures, insulin secretion was significantly increased for NOD mice only, while that of glucagon was not significantly affected. These findings indicate that NOD DC are good candidates for stimulating the NOD mouse &#103 -cell hyperactivity that is observed both in vivo and in vitro, and might, consequently, sensitize NOD islets to an autoimmune attack." @default.
• W2098018211 created "2016-06-24" @default.
• W2098018211 creator A5008337689 @default.
• W2098018211 creator A5009546656 @default.
• W2098018211 creator A5018516458 @default.
• W2098018211 creator A5045386324 @default.
• W2098018211 date "2002-01-01" @default.
• W2098018211 modified "2023-10-01" @default.
• W2098018211 title "Nonobese Diabetic (NOD) Mouse Dendritic Cells Stimulate Insulin Secretion by Prediabetic Islets" @default.
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• W2098018211 doi "https://doi.org/10.1080/0891693021000040575" @default.
• W2098018211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12685873" @default.
• W2098018211 hasPublicationYear "2002" @default.
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