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- W2098020091 abstract "The error-related negativity (ERN) is a negative deflection approximately 50 ms following an erroneous response, and is thought to reflect activity of the anterior cingulate cortex (ACC), a region of the medial prefrontal cortex implicated in the pathophysiology of a number of affective disorders, including generalized anxiety disorder (GAD). Pathological worry, the hallmark of GAD, has been linked to increased error-related brain activity, although no studies to date have examined the ERN among a clinical GAD sample. The present study measured electrocortical indices of error monitoring in a well-characterized, medication-free GAD sample. Brain activity was recorded in 17 GAD and 24 control subjects. The GAD group was characterized by a larger ERN and an increased difference between error and correct trials; a larger ERN was associated with increased self-reported anxiety and depression symptoms. Individuals with GAD have exaggerated early neural responses to errors, consistent with fMRI work implicating ACC abnormalities in GAD." @default.
- W2098020091 created "2016-06-24" @default.
- W2098020091 creator A5063699432 @default.
- W2098020091 creator A5072805379 @default.
- W2098020091 creator A5084570782 @default.
- W2098020091 date "2010-12-01" @default.
- W2098020091 modified "2023-10-14" @default.
- W2098020091 title "Increased error-related brain activity in generalized anxiety disorder" @default.
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