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• W2098022518 abstract "The effects of nicotinamide (NA) deficiency and added NA and 3-aminobenzamide (3AB) on the cytotoxicity and the induction of mutations in Chinese hamster V79-14 cells were investigated. In NA deficiency the addition of NA (up to 4 mM) and 3AB (up to 7.5 mM) was not cytotoxic. The presence of NA prior to exposure to mitomycin C (MMC) or γ-rays produced a dose-dependent increase in the relative cloning ability of DNA-damaged cells. The lethality of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was significantly potentiated by pre-treatment with 5 mM 3AB, but no potentiation by 3AB was observed for MMC, ultraviolet (UV)-B light, or γ-rays." @default.
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• W2098022518 date "1987-01-01" @default.
• W2098022518 modified "2023-09-23" @default.
• W2098022518 title "Nicotinamide starvation and inhibition of poly (ADP-ribose) synthesis enhance the induced mutation in Chinese hamster V79 cells." @default.
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• W2098022518 doi "https://doi.org/10.1269/jrr.28.191" @default.
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