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• W2098031564 abstract "Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The free-radical theory of aging was proposed to explain aging as a consequence of the accumulation of reactive oxygen species (ROS). However, recent findings contradict this theory, and it now seems that mechanisms mediating longevity act through induction of oxidative stress. In fact, calorie restriction - a powerful way of delaying aging - increases ROS accumulation due to stimulation of the basal metabolic rate; moreover, reports show that antioxidant therapy is detrimental to healthy aging. We also now know that genetic manipulation of the insulin-like-growth-factor-1/insulin signal (IIS) has a profound impact on the rate of aging and that the IIS is modulated by calorie restriction and physical exercise. The IIS regulates activation of nitric oxide synthase (eNOS), the activity of which is essential to improving lifespan through calorie restriction, as demonstrated by experiments on eNOS knockout mice. Indeed, eNOS has a key role in maintaining vascular integrity during aging by activating vasorelaxation and allowing migration and angiogenesis. In this review, we will overview current literature on these topics and we will try to convince the reader of the importance of vascular integrity and nitric oxide production in determining healthy aging." @default.
• W2098031564 created "2016-06-24" @default.
• W2098031564 creator A5038393567 @default.
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• W2098031564 creator A5085584750 @default.
• W2098031564 date "2012-11-15" @default.
• W2098031564 modified "2023-10-10" @default.
• W2098031564 title "Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity" @default.
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• W2098031564 cites W1550849850 @default.
• W2098031564 cites W1578616085 @default.
• W2098031564 cites W1631908837 @default.
• W2098031564 cites W1762535185 @default.
• W2098031564 cites W1769035943 @default.
• W2098031564 cites W1933788686 @default.
• W2098031564 cites W1965684670 @default.
• W2098031564 cites W1969307631 @default.
• W2098031564 cites W1971373225 @default.
• W2098031564 cites W1972328139 @default.
• W2098031564 cites W1976654687 @default.
• W2098031564 cites W1980125322 @default.
• W2098031564 cites W1983986440 @default.
• W2098031564 cites W1988126593 @default.
• W2098031564 cites W1988236300 @default.
• W2098031564 cites W1990176711 @default.
• W2098031564 cites W1990826929 @default.
• W2098031564 cites W1992444358 @default.
• W2098031564 cites W1995175684 @default.
• W2098031564 cites W1995188356 @default.
• W2098031564 cites W2001038193 @default.
• W2098031564 cites W2004460254 @default.
• W2098031564 cites W2009300287 @default.
• W2098031564 cites W2012638892 @default.
• W2098031564 cites W2012840031 @default.
• W2098031564 cites W2025128457 @default.
• W2098031564 cites W2026425756 @default.
• W2098031564 cites W2026834839 @default.
• W2098031564 cites W2030429248 @default.
• W2098031564 cites W2034366812 @default.
• W2098031564 cites W2049206418 @default.
• W2098031564 cites W2050478585 @default.
• W2098031564 cites W2056620406 @default.
• W2098031564 cites W2061431107 @default.
• W2098031564 cites W2064044812 @default.
• W2098031564 cites W2069988949 @default.
• W2098031564 cites W2071041881 @default.
• W2098031564 cites W2071290036 @default.
• W2098031564 cites W2075946284 @default.
• W2098031564 cites W2079984893 @default.
• W2098031564 cites W2084944338 @default.
• W2098031564 cites W2091944089 @default.
• W2098031564 cites W2098272848 @default.
• W2098031564 cites W2104391287 @default.
• W2098031564 cites W2106294342 @default.
• W2098031564 cites W2106996966 @default.
• W2098031564 cites W2113684546 @default.
• W2098031564 cites W2116841997 @default.
• W2098031564 cites W2117676499 @default.
• W2098031564 cites W2118874116 @default.
• W2098031564 cites W2119545067 @default.
• W2098031564 cites W2120046557 @default.
• W2098031564 cites W2120670639 @default.
• W2098031564 cites W2122816074 @default.
• W2098031564 cites W2126288862 @default.
• W2098031564 cites W2126493135 @default.
• W2098031564 cites W2127110789 @default.
• W2098031564 cites W2131399515 @default.
• W2098031564 cites W2134269329 @default.
• W2098031564 cites W2134366005 @default.
• W2098031564 cites W2140558936 @default.
• W2098031564 cites W2144791928 @default.
• W2098031564 cites W2155197781 @default.
• W2098031564 cites W2155937098 @default.
• W2098031564 cites W2156136676 @default.
• W2098031564 cites W2159406283 @default.
• W2098031564 cites W2159658224 @default.
• W2098031564 cites W2162306102 @default.
• W2098031564 cites W2164979547 @default.
• W2098031564 cites W2166140382 @default.
• W2098031564 cites W2166665077 @default.
• W2098031564 cites W2169001678 @default.
• W2098031564 cites W2169887452 @default.
• W2098031564 cites W2171282332 @default.
• W2098031564 cites W2185639639 @default.
• W2098031564 cites W2315512556 @default.
• W2098031564 cites W2474753438 @default.
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• W2098031564 doi "https://doi.org/10.1186/1742-4933-9-26" @default.
• W2098031564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538508" @default.
• W2098031564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23153280" @default.
• W2098031564 hasPublicationYear "2012" @default.
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