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- W2098034315 abstract "Abstract A microcalorimetric assay for aldolase isoenzymes in serum, using a Tian-Calvet conduction calorimeter, has been investigated for measurement of activities of serum aldolase toward fructose-1, 6-diphosphate (FDP) and fructose-1-monophosphate (FMP), and of the ratios between these activities as a function of disease state, specifically cancer. Chart deflection measures were found to be proportional to total heat involved and to bear a linear relationship to the amount of aldolase activity toward either substrate in the sample. Differentiation of a cancerous from a noncancerous population was distinct and unambiguous. The ratios of activity toward FDP and FMP were 3. 73 ± 0. 22 and 13. 20 ± 0. 80 in noncancerous and cancerous sera, respectively. The ease and rapidity of assay suggests considerable potential utility as a routine screening method for certain forms of cancer." @default.
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- W2098034315 date "1976-03-01" @default.
- W2098034315 modified "2023-09-27" @default.
- W2098034315 title "Development of a Thermometric Assay for Cancer Differentiation Based on Aldolase Isozyme Patterns" @default.
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- W2098034315 doi "https://doi.org/10.1080/00032717608059099" @default.
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