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- W2098034650 abstract "The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks of cancer' as a framework and consider how this pathway is deregulated. As well as playing a key role in endothelial cell survival and tubular morphogenesis during tumour neovascularization, ERK5 is also emerging as a regulator of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145. Together, these finding underscore the case for further investigation into understanding the role of ERK5 in cancer." @default.
- W2098034650 created "2016-06-24" @default.
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- W2098034650 date "2012-01-19" @default.
- W2098034650 modified "2023-09-30" @default.
- W2098034650 title "ERK5 and its role in tumour development" @default.
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- W2098034650 doi "https://doi.org/10.1042/bst20110663" @default.
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