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- W2098035546 endingPage "593" @default.
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- W2098035546 abstract "Abstract We have generated a panel of transgenic mice expressing HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02, or -C*07:01 as chimeric monochain molecules (i.e., appropriate HLA α1α2 H chain domains fused with a mouse α3 domain and covalently linked to human β2-microglobulin). Whereas surface expression of several transgenes was markedly reduced in recipient mice that coexpressed endogenous H-2 class I molecules, substantial surface expression of all human transgenes was observed in mice lacking H-2 class I molecules. In these HLA monochain transgenic/H-2 class I null mice, we observed a quantitative and qualitative restoration of the peripheral CD8+ T cell repertoire, which exhibited a TCR diversity comparable with C57BL/6 WT mice. Potent epitope-specific, HLA-restricted, IFN-γ–producing CD8+ T cell responses were generated against known reference T cell epitopes after either peptide or DNA immunization. HLA-wise, these new transgenic strains encompass a large proportion of individuals from all major human races and ethnicities. In combination with the previously created HLA-A*02:01 and -B*07:02 transgenic mice, the novel HLA transgenic mice described in this report should be a versatile preclinical animal model that will speed up the identification and optimization of HLA-restricted CD8+ T cell epitopes of potential interest in various autoimmune human diseases and in preclinical evaluation of T cell–based vaccines." @default.
- W2098035546 created "2016-06-24" @default.
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- W2098035546 date "2013-07-15" @default.
- W2098035546 modified "2023-10-09" @default.
- W2098035546 title "HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 Monochain Transgenic/H-2 Class I Null Mice: Novel Versatile Preclinical Models of Human T Cell Responses" @default.
- W2098035546 cites W1483381170 @default.
- W2098035546 cites W1484135921 @default.
- W2098035546 cites W1489716981 @default.
- W2098035546 cites W1522473566 @default.
- W2098035546 cites W1533163141 @default.
- W2098035546 cites W1537609529 @default.
- W2098035546 cites W1555905648 @default.
- W2098035546 cites W1556956934 @default.
- W2098035546 cites W1562504782 @default.
- W2098035546 cites W1574776422 @default.
- W2098035546 cites W1623865608 @default.
- W2098035546 cites W1628217135 @default.
- W2098035546 cites W1664914790 @default.
- W2098035546 cites W1669573844 @default.
- W2098035546 cites W1680337682 @default.
- W2098035546 cites W1760499866 @default.
- W2098035546 cites W1793658769 @default.
- W2098035546 cites W1822723049 @default.
- W2098035546 cites W1912307887 @default.
- W2098035546 cites W1928008970 @default.
- W2098035546 cites W1970589909 @default.
- W2098035546 cites W1971675671 @default.
- W2098035546 cites W1972914770 @default.
- W2098035546 cites W1975991970 @default.
- W2098035546 cites W1978480556 @default.
- W2098035546 cites W1981338942 @default.
- W2098035546 cites W1983760021 @default.
- W2098035546 cites W1986353809 @default.
- W2098035546 cites W1990359665 @default.
- W2098035546 cites W1993529526 @default.
- W2098035546 cites W1995218568 @default.
- W2098035546 cites W1996017127 @default.
- W2098035546 cites W1999164266 @default.
- W2098035546 cites W2004751612 @default.
- W2098035546 cites W2005166988 @default.
- W2098035546 cites W2006298064 @default.
- W2098035546 cites W2009271567 @default.
- W2098035546 cites W2009871383 @default.
- W2098035546 cites W2010371508 @default.
- W2098035546 cites W2020857625 @default.
- W2098035546 cites W2022274936 @default.
- W2098035546 cites W2026501024 @default.
- W2098035546 cites W2030510044 @default.
- W2098035546 cites W2034298592 @default.
- W2098035546 cites W2041426680 @default.
- W2098035546 cites W2042155609 @default.
- W2098035546 cites W2042525092 @default.
- W2098035546 cites W2044420264 @default.
- W2098035546 cites W2048725216 @default.
- W2098035546 cites W2049561817 @default.
- W2098035546 cites W2053054271 @default.
- W2098035546 cites W2060137087 @default.
- W2098035546 cites W2064873017 @default.
- W2098035546 cites W2066023902 @default.
- W2098035546 cites W2070910664 @default.
- W2098035546 cites W2073739597 @default.
- W2098035546 cites W2076809878 @default.
- W2098035546 cites W2077116918 @default.
- W2098035546 cites W2077466422 @default.
- W2098035546 cites W2079319457 @default.
- W2098035546 cites W2084443909 @default.
- W2098035546 cites W2087244840 @default.
- W2098035546 cites W2091866956 @default.
- W2098035546 cites W2101966786 @default.
- W2098035546 cites W2108777421 @default.
- W2098035546 cites W2112184010 @default.
- W2098035546 cites W2119863063 @default.
- W2098035546 cites W2120766171 @default.
- W2098035546 cites W2121192317 @default.
- W2098035546 cites W2123984667 @default.
- W2098035546 cites W2134182833 @default.
- W2098035546 cites W2138205821 @default.
- W2098035546 cites W2139721896 @default.
- W2098035546 cites W2142424504 @default.
- W2098035546 cites W2143359784 @default.
- W2098035546 cites W2147402069 @default.
- W2098035546 cites W2148368831 @default.
- W2098035546 cites W2150377368 @default.
- W2098035546 cites W2152994458 @default.
- W2098035546 cites W2164339006 @default.