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- W2098035977 endingPage "879" @default.
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- W2098035977 abstract "Background & Aims: Celiac disease is a gluten-induced enteropathy characterized by the presence of gliadin-specific CD4+ T cells in the lamina propria and by a prominent intraepithelial T-cell infiltration of unknown mechanism. The aim of this study was to characterize the subset(s) of intraepithelial lymphocytes (IELs) expanding during active celiac disease to provide insights into the mechanisms involved in their expansion. Methods: Flow-cytometric analysis of isolated IELs and/or immunohistochemical staining of frozen sections were performed in 51 celiac patients and 50 controls with a panel of monoclonal antibodies against T-cell and natural killer (NK) receptors. In addition, in vitro studies were performed to identify candidate stimuli for NK receptor expression. Results: In normal intestine, different proportions of IELs, which were mainly T cells, expressed the NK receptors CD94/NKG2, NKR-P1A, KIR2D/3D, NKp46, Pen5, or CD56. During the active phase of celiac disease, the frequency of CD94+ IELs, which were mostly αβ T cells, was conspicuously increased over controls. In contrast, the expression of other NK markers was not modified. Furthermore, expression of CD94 could be selectively induced in vitro by T-cell receptor activation and/or interleukin 15, a cytokine produced by intestinal epithelial cells. Conclusions: The gut epithelium favors the development of T cells that express NK receptors. In active celiac disease, there is a specific and selective increase of IELs expressing CD94, the HLA-E–specific NK receptor that may be related to T-cell receptor activation and/or interleukin 15 secretion.GASTROENTEROLOGY 2000;118:867-879" @default.
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- W2098035977 date "2000-05-01" @default.
- W2098035977 modified "2023-10-18" @default.
- W2098035977 title "Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease" @default.
- W2098035977 cites W1502107623 @default.
- W2098035977 cites W1572146029 @default.
- W2098035977 cites W1576553969 @default.
- W2098035977 cites W1576698873 @default.
- W2098035977 cites W1638058526 @default.
- W2098035977 cites W1641758654 @default.
- W2098035977 cites W1921962230 @default.
- W2098035977 cites W1927667480 @default.
- W2098035977 cites W1972810072 @default.
- W2098035977 cites W1972931136 @default.
- W2098035977 cites W1973068990 @default.
- W2098035977 cites W1974954844 @default.
- W2098035977 cites W1977740246 @default.
- W2098035977 cites W1986762586 @default.
- W2098035977 cites W1989679330 @default.
- W2098035977 cites W1994255893 @default.
- W2098035977 cites W1996032151 @default.
- W2098035977 cites W1996288597 @default.
- W2098035977 cites W1999201841 @default.
- W2098035977 cites W2001407458 @default.
- W2098035977 cites W2001985853 @default.
- W2098035977 cites W2014208459 @default.
- W2098035977 cites W2022609860 @default.
- W2098035977 cites W2023628451 @default.
- W2098035977 cites W2033398975 @default.
- W2098035977 cites W2034486895 @default.
- W2098035977 cites W2037133606 @default.
- W2098035977 cites W2043856196 @default.
- W2098035977 cites W2047552280 @default.
- W2098035977 cites W2048796508 @default.
- W2098035977 cites W2053585436 @default.
- W2098035977 cites W2056204715 @default.
- W2098035977 cites W2058522060 @default.
- W2098035977 cites W2064449233 @default.
- W2098035977 cites W2075172354 @default.
- W2098035977 cites W2078508483 @default.
- W2098035977 cites W2080800384 @default.
- W2098035977 cites W2080891856 @default.
- W2098035977 cites W2089467155 @default.
- W2098035977 cites W2089484373 @default.
- W2098035977 cites W2093250647 @default.
- W2098035977 cites W2098130458 @default.
- W2098035977 cites W2101103569 @default.
- W2098035977 cites W2102453705 @default.
- W2098035977 cites W2106901511 @default.
- W2098035977 cites W2106951285 @default.
- W2098035977 cites W2110000889 @default.
- W2098035977 cites W2112926547 @default.
- W2098035977 cites W2114270498 @default.
- W2098035977 cites W2116171543 @default.
- W2098035977 cites W2116955690 @default.
- W2098035977 cites W2121895986 @default.
- W2098035977 cites W2122144067 @default.
- W2098035977 cites W2123859180 @default.
- W2098035977 cites W2126722183 @default.
- W2098035977 cites W2131132948 @default.
- W2098035977 cites W2131596029 @default.
- W2098035977 cites W2133184513 @default.
- W2098035977 cites W2135364324 @default.
- W2098035977 cites W2136436255 @default.
- W2098035977 cites W2139056292 @default.
- W2098035977 cites W2145270889 @default.
- W2098035977 cites W2146555062 @default.
- W2098035977 cites W2149711457 @default.
- W2098035977 cites W2152989802 @default.
- W2098035977 cites W2159199533 @default.
- W2098035977 cites W2160520392 @default.
- W2098035977 cites W2163466184 @default.
- W2098035977 cites W2164728443 @default.
- W2098035977 cites W278851545 @default.
- W2098035977 cites W4294305087 @default.