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- W2098040260 abstract "To investigate the relationship between in vivo brain fibrillar amyloid-beta (Aβ) burden, measured by 11C-labeled Pittsburgh Compound B (11C-PiB) retention, and age-at-onset in Alzheimer's disease (AD) patients. Twenty-two AD patients including 11 early-onset AD (EOAD: onset <65 years) and 11 late-onset AD (LOAD: onset ≥ 65 years) cases with matched dementia severity, duration of illness, and apolipoprotein E ∊4 allele number received 11C-PiB PET scans. Both region of interest and voxel-based analyses were performed to compare 11C-PiB retention between EOAD and LOAD group, and to test linear relationship between age-at-onset and 11C-PiB retention. Both ROI- and voxel-based analyses revealed that EOAD patients had significantly higher 11C-PIB retentions than LOAD patients in diffuse brain regions including frontal, lateral parietal, lateral temporal and occipital cortex, and basal ganglia. Significant negative correlations were found between age-at-onset and 11C-PiB retention for all subjects in similar brain regions. Secondary subgroup analyses showed that such inverse relationship was prominent only in LOAD, but not in EOAD. Inverse linear relationship between age-at-onset and fibrillar Aβ deposition, prominent in senile ages in particular, is probably associated with aging-related decline of brain reserve or cognitive reserve and increase of vulnerability to Aβ toxicity, and may explain gradual increase of the prevalence or incidence of AD after early sixties." @default.
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- W2098040260 date "2010-07-01" @default.
- W2098040260 modified "2023-09-23" @default.
- W2098040260 title "IC‐P‐097: Relationship of Fibrillar Beta‐Amyloid Burden with Age‐at‐Onset in Alzheimer's Disease" @default.
- W2098040260 doi "https://doi.org/10.1016/j.jalz.2010.05.111" @default.
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