Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098049360> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2098049360 endingPage "228" @default.
- W2098049360 startingPage "218" @default.
- W2098049360 abstract "Primary liver cancer, also known as hepatocellular carcinoma (HCC), is one of the most lethal cancers having worldwide prevalence. Although most HCC cases are reported in the developing countries of Asia and Africa, there has been an alarming increase in HCC cases in Western Europe as well as United States. Chronic liver diseases, viral hepatitis, alcoholism as well as dietary carcinogens, such as aflatoxins and nitrosoamines, contribute to HCC. Liver transplantation as well as surgical resection at best offer limited treatment options. Thus, there exists a critical need to investigate and evaluate possible alternative chemopreventive and therapeutic strategies which may be effective in the control of liver cancer. HCC, most often, develops and progresses in a milieu of oxidative stress and inflammation. Phytochemicals, such as dietary polyphenols endowed with potent antioxidant as well as anti-inflammatory properties, provide a suitable alternative in affording alleviation of HCC. Curcumin, the principal polyphenolic curcuminoid, obtained from the turmeric rhizome Curcuma longa has long been used to cure several chronic ailments, such as neoplastic and neurodegenerative diseases. Studies suggest that curcumin may have antitumor, antioxidant, and anti-inflammatory properties. This article reviews the effects of curcumin in preclinical in vitro and in vivo models of HCC with particular emphasis to its antioxidant, apoptotic and anti-inflammatory effects as well as involvement in various molecular signaling mechanisms. This review also discusses potential challenges involved in the use of curcumin in HCC, such as bioavailability, pharmacokinetics, drug delivery as well as paucity of clinical studies. Keywords: Chemoprevention, curcumin, inflammation, liver cancer, oxidative stress, therapy, hepatocellular carcinoma (HCC), Chronic liver diseases, viral hepatitis, aflatoxins, nitrosoamines, chemopreventive and therapeutic strategies, dietary polyphenols" @default.
- W2098049360 created "2016-06-24" @default.
- W2098049360 creator A5019852381 @default.
- W2098049360 creator A5048675624 @default.
- W2098049360 creator A5090394722 @default.
- W2098049360 date "2012-01-01" @default.
- W2098049360 modified "2023-10-14" @default.
- W2098049360 title "Curcumin and Liver Cancer: A Review" @default.
- W2098049360 doi "https://doi.org/10.2174/138920112798868791" @default.
- W2098049360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21466422" @default.
- W2098049360 hasPublicationYear "2012" @default.
- W2098049360 type Work @default.
- W2098049360 sameAs 2098049360 @default.
- W2098049360 citedByCount "212" @default.
- W2098049360 countsByYear W20980493602012 @default.
- W2098049360 countsByYear W20980493602013 @default.
- W2098049360 countsByYear W20980493602014 @default.
- W2098049360 countsByYear W20980493602015 @default.
- W2098049360 countsByYear W20980493602016 @default.
- W2098049360 countsByYear W20980493602017 @default.
- W2098049360 countsByYear W20980493602018 @default.
- W2098049360 countsByYear W20980493602019 @default.
- W2098049360 countsByYear W20980493602020 @default.
- W2098049360 countsByYear W20980493602021 @default.
- W2098049360 countsByYear W20980493602022 @default.
- W2098049360 countsByYear W20980493602023 @default.
- W2098049360 crossrefType "journal-article" @default.
- W2098049360 hasAuthorship W2098049360A5019852381 @default.
- W2098049360 hasAuthorship W2098049360A5048675624 @default.
- W2098049360 hasAuthorship W2098049360A5090394722 @default.
- W2098049360 hasConcept C121608353 @default.
- W2098049360 hasConcept C126322002 @default.
- W2098049360 hasConcept C2776151105 @default.
- W2098049360 hasConcept C2776231280 @default.
- W2098049360 hasConcept C2777070074 @default.
- W2098049360 hasConcept C2777230291 @default.
- W2098049360 hasConcept C2778019345 @default.
- W2098049360 hasConcept C2778250585 @default.
- W2098049360 hasConcept C502942594 @default.
- W2098049360 hasConcept C556039675 @default.
- W2098049360 hasConcept C71924100 @default.
- W2098049360 hasConcept C98274493 @default.
- W2098049360 hasConceptScore W2098049360C121608353 @default.
- W2098049360 hasConceptScore W2098049360C126322002 @default.
- W2098049360 hasConceptScore W2098049360C2776151105 @default.
- W2098049360 hasConceptScore W2098049360C2776231280 @default.
- W2098049360 hasConceptScore W2098049360C2777070074 @default.
- W2098049360 hasConceptScore W2098049360C2777230291 @default.
- W2098049360 hasConceptScore W2098049360C2778019345 @default.
- W2098049360 hasConceptScore W2098049360C2778250585 @default.
- W2098049360 hasConceptScore W2098049360C502942594 @default.
- W2098049360 hasConceptScore W2098049360C556039675 @default.
- W2098049360 hasConceptScore W2098049360C71924100 @default.
- W2098049360 hasConceptScore W2098049360C98274493 @default.
- W2098049360 hasIssue "1" @default.
- W2098049360 hasLocation W20980493601 @default.
- W2098049360 hasLocation W20980493602 @default.
- W2098049360 hasOpenAccess W2098049360 @default.
- W2098049360 hasPrimaryLocation W20980493601 @default.
- W2098049360 hasRelatedWork W1991178530 @default.
- W2098049360 hasRelatedWork W2076046474 @default.
- W2098049360 hasRelatedWork W2079207441 @default.
- W2098049360 hasRelatedWork W2407222683 @default.
- W2098049360 hasRelatedWork W2784143496 @default.
- W2098049360 hasRelatedWork W2938124300 @default.
- W2098049360 hasRelatedWork W3043313011 @default.
- W2098049360 hasRelatedWork W4304688893 @default.
- W2098049360 hasRelatedWork W4313329777 @default.
- W2098049360 hasRelatedWork W4385771485 @default.
- W2098049360 hasVolume "13" @default.
- W2098049360 isParatext "false" @default.
- W2098049360 isRetracted "false" @default.
- W2098049360 magId "2098049360" @default.
- W2098049360 workType "article" @default.