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- W2098069894 abstract "Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (α-syn). This study investigated whether passive immunization with a novel monoclonal α-syn antibody (9E4) against the C-terminus (CT) of α-syn was able to cross into the CNS and ameliorate the deficits associated with α-syn accumulation. In this study we demonstrate that 9E4 was effective at reducing behavioral deficits in the water maze, moreover, immunization with 9E4 reduced the accumulation of calpain-cleaved α-syn in axons and synapses and the associated neurodegenerative deficits. In vivo studies demonstrated that 9E4 traffics into the CNS, binds to cells that display α-syn accumulation and promotes α-syn clearance via the lysosomal pathway. These results suggest that passive immunization with monoclonal antibodies against the CT of α-syn may be of therapeutic relevance in patients with PD and DLB." @default.
- W2098069894 created "2016-06-24" @default.
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- W2098069894 date "2011-04-29" @default.
- W2098069894 modified "2023-10-03" @default.
- W2098069894 title "Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease" @default.
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- W2098069894 doi "https://doi.org/10.1371/journal.pone.0019338" @default.
- W2098069894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3084838" @default.
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