FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098082504> ?p ?o ?g. }

• W2098082504 endingPage "1094" @default.
• W2098082504 startingPage "1087" @default.
• W2098082504 abstract "Abstract Background & Aims Recent data reported the increased expression of forkhead box protein 3 (FOXP3), the well known master regulator of CD4 + C25 + regulatory T cells, in hepatocellular carcinoma (HCC) cells. However, the mechanisms remain unknown. We previously showed that preS2, one of important regulatory proteins encoded by HBV, triggers transactivation of hTERT in malignant hepatocytes. Here, we aimed to explore the role of preS2 in regulating FOXP3 expression in HCC. Methods FOXP 3 expression was detected by RT ‐ PCR , Western blot and immunohistochemical staining. Cotransfection and si RNA knockdown were involved to study the regulation effects of preS2 on FOXP 3 expression in cultured HCC cell lines. Luciferase reporter assay and EMSA assay were performed to explore the mechanism of preS2‐mediated FOXP 3 upregulation. Results Immunohistochemical staining detected significant increased FOXP 3 expression in malignant hepatocytes from sections of HCC patients. The total FOXP 3 expression in hepatocytes from patients with HB sAg‐positive HCC was significantly increased compared to that of HBV ‐negative HCC s ( P = 0.002). In accordance, preS2 overexpression enhanced FOXP 3 expression in HCC cell lines, while preS2 knockdown significantly reduced FOXP 3 expression in HBV ‐integrated HepG2.2.15 cells. Results of cotransfection and luciferase report assay showed that preS2 transactivated FOXP 3 promoter in a dose‐dependent manner. Further study identified the AP ‐1 binding site at 20 bp region from −465 bp to −445 bp of FOXP 3 promoter was responsible for preS2‐induced FOXP 3 transcriptional activation. Conclusions Our data here, for the first time, provided direct evidence to demonstrate that preS2 oncoprotein encoded by HBV transactivated FOXP3 transcription in HCC cells." @default.
• W2098082504 created "2016-06-24" @default.
• W2098082504 creator A5005395977 @default.
• W2098082504 creator A5009283579 @default.
• W2098082504 creator A5014451075 @default.
• W2098082504 creator A5018814025 @default.
• W2098082504 creator A5024659860 @default.
• W2098082504 creator A5030924064 @default.
• W2098082504 creator A5041946160 @default.
• W2098082504 creator A5052274720 @default.
• W2098082504 creator A5054280511 @default.
• W2098082504 creator A5065752249 @default.
• W2098082504 creator A5070081604 @default.
• W2098082504 creator A5076153061 @default.
• W2098082504 date "2014-08-08" @default.
• W2098082504 modified "2023-10-04" @default.
• W2098082504 title "HBV preS2 transactivates FOXP3 expression in malignant hepatocytes" @default.
• W2098082504 cites W1539668795 @default.
• W2098082504 cites W1939804351 @default.
• W2098082504 cites W1963858122 @default.
• W2098082504 cites W1982306836 @default.
• W2098082504 cites W1982533501 @default.
• W2098082504 cites W1990561061 @default.
• W2098082504 cites W1999152495 @default.
• W2098082504 cites W2003833115 @default.
• W2098082504 cites W2004708987 @default.
• W2098082504 cites W2014256787 @default.
• W2098082504 cites W2016316937 @default.
• W2098082504 cites W2019060341 @default.
• W2098082504 cites W2040358727 @default.
• W2098082504 cites W2040606106 @default.
• W2098082504 cites W2040906389 @default.
• W2098082504 cites W2072012088 @default.
• W2098082504 cites W2092590786 @default.
• W2098082504 cites W2099865291 @default.
• W2098082504 cites W2103637700 @default.
• W2098082504 cites W2107336310 @default.
• W2098082504 cites W2109351460 @default.
• W2098082504 cites W2111110299 @default.
• W2098082504 cites W2130486201 @default.
• W2098082504 cites W2130961909 @default.
• W2098082504 cites W2136926484 @default.
• W2098082504 cites W2140481064 @default.
• W2098082504 cites W2144848888 @default.
• W2098082504 cites W2150678612 @default.
• W2098082504 cites W2150708887 @default.
• W2098082504 cites W2158585862 @default.
• W2098082504 cites W2162119603 @default.
• W2098082504 cites W2164049628 @default.
• W2098082504 cites W2314866596 @default.
• W2098082504 doi "https://doi.org/10.1111/liv.12642" @default.
• W2098082504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25047684" @default.
• W2098082504 hasPublicationYear "2014" @default.
• W2098082504 type Work @default.
• W2098082504 sameAs 2098082504 @default.
• W2098082504 citedByCount "14" @default.
• W2098082504 countsByYear W20980825042015 @default.
• W2098082504 countsByYear W20980825042017 @default.
• W2098082504 countsByYear W20980825042018 @default.
• W2098082504 countsByYear W20980825042019 @default.
• W2098082504 countsByYear W20980825042020 @default.
• W2098082504 countsByYear W20980825042021 @default.
• W2098082504 countsByYear W20980825042022 @default.
• W2098082504 crossrefType "journal-article" @default.
• W2098082504 hasAuthorship W2098082504A5005395977 @default.
• W2098082504 hasAuthorship W2098082504A5009283579 @default.
• W2098082504 hasAuthorship W2098082504A5014451075 @default.
• W2098082504 hasAuthorship W2098082504A5018814025 @default.
• W2098082504 hasAuthorship W2098082504A5024659860 @default.
• W2098082504 hasAuthorship W2098082504A5030924064 @default.
• W2098082504 hasAuthorship W2098082504A5041946160 @default.
• W2098082504 hasAuthorship W2098082504A5052274720 @default.
• W2098082504 hasAuthorship W2098082504A5054280511 @default.
• W2098082504 hasAuthorship W2098082504A5065752249 @default.
• W2098082504 hasAuthorship W2098082504A5070081604 @default.
• W2098082504 hasAuthorship W2098082504A5076153061 @default.
• W2098082504 hasConcept C104317684 @default.
• W2098082504 hasConcept C127561419 @default.
• W2098082504 hasConcept C1292079 @default.
• W2098082504 hasConcept C1491633281 @default.
• W2098082504 hasConcept C153911025 @default.
• W2098082504 hasConcept C173396325 @default.
• W2098082504 hasConcept C203014093 @default.
• W2098082504 hasConcept C204232928 @default.
• W2098082504 hasConcept C2776415932 @default.
• W2098082504 hasConcept C502942594 @default.
• W2098082504 hasConcept C54355233 @default.
• W2098082504 hasConcept C81885089 @default.
• W2098082504 hasConcept C86339819 @default.
• W2098082504 hasConcept C86803240 @default.
• W2098082504 hasConceptScore W2098082504C104317684 @default.
• W2098082504 hasConceptScore W2098082504C127561419 @default.
• W2098082504 hasConceptScore W2098082504C1292079 @default.
• W2098082504 hasConceptScore W2098082504C1491633281 @default.
• W2098082504 hasConceptScore W2098082504C153911025 @default.
• W2098082504 hasConceptScore W2098082504C173396325 @default.
• W2098082504 hasConceptScore W2098082504C203014093 @default.
• W2098082504 hasConceptScore W2098082504C204232928 @default.

• next