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- W2098084008 abstract "Expulsion of the gastro-intestinal nematode Trichinella spiralis is associated with a pronounced mastocytosis mediated by a T helper (Th) 2 type response involving interleukin (IL)-4 and IL-13. Here we demonstrate that IL-10 is a key regulator of protective immune responses against T. spiralis in vivo. IL-10 knockout mice or normal mice treated with a neutralizing anti-IL-10 receptor antibody are highly susceptible to a primary T. spiralis infection and show significantly delayed adult worm expulsion. Depletion of IL-10 resulted in elevated Th1 and Th2 cytokine responses but significantly reduced numbers of mucosal mast cells in the jejunum. Interestingly, the increase in IFN-γ detected in the absence of IL-10 resulted in increased immunity to larval stages. Hence, IL-10 has a negative effect on immunity to the tissue dwelling larval stages of T. spiralis but plays a significant biological role as an in vivo regulator of intestinal mast cell responses and is crucially involved in protection against adult stages of intestinal parasites in vivo." @default.
- W2098084008 created "2016-06-24" @default.
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- W2098084008 date "2003-09-01" @default.
- W2098084008 modified "2023-10-18" @default.
- W2098084008 title "Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites" @default.
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- W2098084008 doi "https://doi.org/10.1002/eji.200324082" @default.
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