FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098085047> ?p ?o ?g. }

• W2098085047 endingPage "745" @default.
• W2098085047 startingPage "734" @default.
• W2098085047 abstract "The metabolic changes that occur as a function of time in MG-63 osteosarcoma three-dimensional tumor spheroids undergoing radiation-induced apoptosis were studied using high-resolution proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. Specifically, the (1)H-NMR spectra of MG-63 spheroids collected at 24, 48 and 72 h after exposure to 5 Gy of ionizing radiation were compared to the spectra of their respective controls. Small spheroids (about 50-80 microm in diameter) with no hypoxic center were used. Apoptosis was verified by both staining of spheroid DNA with the Hoechst 33258 dye and determination of caspase 3 enzyme activity at the three times examined. The results demonstrate that, as the percentage of apoptosis rises with time after exposure to ionizing radiation, the metabolic changes that take place in MG-63 spheroids follow very precise temporal dynamics. In particular, significant time-related increases in both CH(2) and CH(3) mobile lipids, considered by many authors as markers of apoptosis, were observed. In addition, temporal variations were also observed in choline-containing metabolites, reduced glutathione (GSH), glutamine/glutamate, taurine, alanine, creatine/phosphocreatine and lactate. These data show that in addition to CH(2) and CH(3) lipids, other metabolites can also be extremely useful in a deeper understanding of the temporal dynamics of radiation-induced apoptosis. This comprehension is particularly important in spheroids, a cell model of great complexity that resembles in vivo tumors much more closely than monolayer cultures. Ultimately, it is hoped that such studies can help to evaluate the outcome of radiotherapy protocols more accurately." @default.
• W2098085047 created "2016-06-24" @default.
• W2098085047 creator A5019321390 @default.
• W2098085047 creator A5039881830 @default.
• W2098085047 creator A5040020004 @default.
• W2098085047 creator A5061315099 @default.
• W2098085047 creator A5081142252 @default.
• W2098085047 creator A5088328766 @default.
• W2098085047 creator A5091162026 @default.
• W2098085047 date "2006-11-01" @default.
• W2098085047 modified "2023-09-24" @default.
• W2098085047 title "Temporal Dynamics of¹H-NMR-Visible Metabolites during Radiation-Induced Apoptosis in MG-63 Human Osteosarcoma Spheroids" @default.
• W2098085047 cites W1487906855 @default.
• W2098085047 cites W1581565952 @default.
• W2098085047 cites W1963522191 @default.
• W2098085047 cites W1964997589 @default.
• W2098085047 cites W1967056315 @default.
• W2098085047 cites W1968950322 @default.
• W2098085047 cites W1969095053 @default.
• W2098085047 cites W1973036015 @default.
• W2098085047 cites W1979187245 @default.
• W2098085047 cites W1981667064 @default.
• W2098085047 cites W1981781943 @default.
• W2098085047 cites W1985719136 @default.
• W2098085047 cites W1988365805 @default.
• W2098085047 cites W1988841191 @default.
• W2098085047 cites W1995143361 @default.
• W2098085047 cites W1995262495 @default.
• W2098085047 cites W1995293151 @default.
• W2098085047 cites W1996459206 @default.
• W2098085047 cites W1997624484 @default.
• W2098085047 cites W2000971507 @default.
• W2098085047 cites W2006086206 @default.
• W2098085047 cites W2006819816 @default.
• W2098085047 cites W2007466881 @default.
• W2098085047 cites W2007923494 @default.
• W2098085047 cites W2011487437 @default.
• W2098085047 cites W2017728303 @default.
• W2098085047 cites W2017795729 @default.
• W2098085047 cites W2021191809 @default.
• W2098085047 cites W2024275778 @default.
• W2098085047 cites W2025106434 @default.
• W2098085047 cites W2035557053 @default.
• W2098085047 cites W2042782796 @default.
• W2098085047 cites W2059706127 @default.
• W2098085047 cites W2064458964 @default.
• W2098085047 cites W2065228338 @default.
• W2098085047 cites W2067127132 @default.
• W2098085047 cites W2069119488 @default.
• W2098085047 cites W2070101406 @default.
• W2098085047 cites W2071697240 @default.
• W2098085047 cites W2076755375 @default.
• W2098085047 cites W2077044903 @default.
• W2098085047 cites W2079442902 @default.
• W2098085047 cites W2079643600 @default.
• W2098085047 cites W2096891387 @default.
• W2098085047 cites W2149816855 @default.
• W2098085047 cites W2154369685 @default.
• W2098085047 cites W2160325550 @default.
• W2098085047 cites W2187377427 @default.
• W2098085047 cites W2261854986 @default.
• W2098085047 cites W2276638120 @default.
• W2098085047 cites W2290705040 @default.
• W2098085047 cites W2319243171 @default.
• W2098085047 cites W4230891350 @default.
• W2098085047 cites W4239777753 @default.
• W2098085047 cites W63890287 @default.
• W2098085047 doi "https://doi.org/10.1667/rr0635.1" @default.
• W2098085047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17067211" @default.
• W2098085047 hasPublicationYear "2006" @default.
• W2098085047 type Work @default.
• W2098085047 sameAs 2098085047 @default.
• W2098085047 citedByCount "12" @default.
• W2098085047 countsByYear W20980850472013 @default.
• W2098085047 countsByYear W20980850472014 @default.
• W2098085047 countsByYear W20980850472018 @default.
• W2098085047 countsByYear W20980850472020 @default.
• W2098085047 crossrefType "journal-article" @default.
• W2098085047 hasAuthorship W2098085047A5019321390 @default.
• W2098085047 hasAuthorship W2098085047A5039881830 @default.
• W2098085047 hasAuthorship W2098085047A5040020004 @default.
• W2098085047 hasAuthorship W2098085047A5061315099 @default.
• W2098085047 hasAuthorship W2098085047A5081142252 @default.
• W2098085047 hasAuthorship W2098085047A5088328766 @default.
• W2098085047 hasAuthorship W2098085047A5091162026 @default.
• W2098085047 hasConcept C111337013 @default.
• W2098085047 hasConcept C121332964 @default.
• W2098085047 hasConcept C12554922 @default.
• W2098085047 hasConcept C134018914 @default.
• W2098085047 hasConcept C150903083 @default.
• W2098085047 hasConcept C175369904 @default.
• W2098085047 hasConcept C18231593 @default.
• W2098085047 hasConcept C185544564 @default.
• W2098085047 hasConcept C185592680 @default.
• W2098085047 hasConcept C190283241 @default.
• W2098085047 hasConcept C202751555 @default.
• W2098085047 hasConcept C207001950 @default.
• W2098085047 hasConcept C2778626300 @default.

• next