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- W2098085299 abstract "Several glycoconjugates, alpha-D-mannopyranosyl, beta-L-fucopyranosyl, alpha-L-rhamnopyranosyl, beta-D-glucopyranosyl and beta-D-galactopyranosyl human serum albumin, were synthesized using C9-tether and radiolabeled with 99mTc and 131I. Both 99mTc and 131I radiolabeled neoglycoalbumins had considerable stability and exhibited similar biodistribution patterns within the experimental limits. The results of biodistribution studies can be explained from the in vitro observations that 99mTc-beta-D-galactopyranosyl albumin binds to hepatic binding protein in liver in a dose-dependent fashion. The radiolabeled glycoalbumins derived from D-mannopyranose and L-fucopyranose also bind in a dose-dependent fashion to the receptors present in the liver sinusoidal cells and spleen macrophages. The beta-D-glucopyranosyl and alpha-L-rhamnopyranosyl neoglycoalbumins accumulate nonspecifically in liver and spleen." @default.
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- W2098085299 date "1995-07-01" @default.
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- W2098085299 title "Syntheses of several 99mTc and 131I labeled neoglycoalbumins and their differential uptake patterns in animal biodistribution experiments" @default.
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- W2098085299 doi "https://doi.org/10.1016/0969-8051(95)00003-g" @default.
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