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- W2098090448 abstract "The release of propranolol hydrochloride from matrices containing ethylcellulose 7 or 10 cP at different polymer contents and different pressures were examined. As the polymer content of the matrices increased, the release rate of the drug decreased, whereas the release exponents remained almost unchanged, indicating that the polymer content did not affect the release mechanism. As the particle size of either ethylcellulose increased, the release rates increased, indicating that penetration of water into the matrices was facilitated when coarser particle size fractions were used and the release exponents correspondingly increased. The highest value, n = 0.88, was obtained for ethylcellulose 10 cP with the 425–355 μm fraction. Compaction pressures up to 39.4 MNm−2 affected release rates whereas, compression pressure from 78.7 to 393.7 MNm−2 did not further modify the release rate. As the proportion of HPMC or NaCMC in admixture with ethylcellulose increased, the release rates gradually increased. Admixture of HPMC with ethylcellulose did not change the release exponent whereas a wide range of release exponent from matrices containing NaCMC: ethylcellulose was obtained. Differential scanning calorimetry was used to quantify the water uptake processes. Wafers containing ethylcellulose: HPMC displayed an approximate 39% of uptake after 5 min of contact with water, compared with values of 32 and 7% for HPMC and ethylcellulose, respectively, at the same time, indicating that wafers containing 1:1 HPMC:ethylcellulose were able to absorb more water than HPMC K4M at the commencement of the water uptake." @default.
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- W2098090448 title "Effects of polymer particle size, compaction pressure and hydrophilic polymers on drug release from matrices containing ethylcellulose" @default.
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