FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098091211> ?p ?o ?g. }

• W2098091211 endingPage "18" @default.
• W2098091211 startingPage "9" @default.
• W2098091211 abstract "Adrenal medullary hyperplasia and pheochromocytomas are induced in rats by a variety of non-genotoxic agents, and we have hypothesized that these agents induce lesions indirectly by stimulating chromaffin cell proliferation. Vitamin D3, which has not been previously associated with adrenal medullary proliferative lesions, is the most potent in vivo stimulus to chromaffin cell proliferation yet identified. The present investigation utilized the vitamin D3 model to prospectively test the relationship between mitogenicity and focal proliferative lesions in the adrenal medulla and to determine early events in the pathogenesis of these lesions. Charles River Crl:CD BR rats were treated with 0; 5000; 10,000; or 20,000 IU/kg/day of vitamin D3 in corn oil (5 ml/kg) by oral intubation. Rats were killed after 4, 8, 12, or 26 weeks of treatment, following a final week of labeling with bromodeoxyuridine (BrdU) using a mini-pump. Adrenal sections were double-stained for BrdU and phenylethanolamine-N-methyl transferase (PNMT) to discriminate epinephrine (E) from norepinephrine (NE) cells or for vesicular acetylcholine transporter (VAchT) to identify cholinergic nerve endings. Vitamin D3 caused a 4-5-fold increase in BrdU labeling at week 4, diminishing to a 2-fold increase by week 26. An initial preponderance of labeled E cells gave way to a preponderance of labeled NE cells. By week 26, 17/19 (89%) animals receiving the 2 highest doses of vitamin D3 had focal adrenal medullary proliferative lesions, in contrast to an absence of lesions in control rats. The lesions encompassed a spectrum including BrdU-labeled hot spots not readily visible on H and E sections, hyperplastic nodules, and pheochromocytomas. Lesions were usually multicentric, bilateral, and peripheral in location, and almost all were PNMT-negative. The lesions were not cholinergically innervated, suggesting autonomous proliferation. Hot spots, hyperplastic nodules, and pheochromocytomas appear to represent a continuum rather than separate entities. Their development might involve selective responses of chromaffin cell subsets to mitogenic signals, influenced by both innervation and corticomedullary interactions. A number of non-genotoxic compounds that induce pheochromocytomas in rats are known to affect calcium homeostasis. The results of this study provide further evidence to support the hypothesis that altered calcium homeostasis is indirectly involved in the pathogenesis of pheochromocytomas, via effects on chromaffin cell proliferation." @default.
• W2098091211 created "2016-06-24" @default.
• W2098091211 creator A5009606299 @default.
• W2098091211 creator A5033969852 @default.
• W2098091211 creator A5035581331 @default.
• W2098091211 creator A5068467304 @default.
• W2098091211 creator A5082605513 @default.
• W2098091211 creator A5087511546 @default.
• W2098091211 date "1999-09-01" @default.
• W2098091211 modified "2023-10-03" @default.
• W2098091211 title "Vitamin D3-induced proliferative lesions in the rat adrenal medulla" @default.
• W2098091211 cites W185139017 @default.
• W2098091211 cites W1853725381 @default.
• W2098091211 cites W1886438078 @default.
• W2098091211 cites W1895093430 @default.
• W2098091211 cites W1917454445 @default.
• W2098091211 cites W1970218284 @default.
• W2098091211 cites W1972963160 @default.
• W2098091211 cites W1974448814 @default.
• W2098091211 cites W1980005559 @default.
• W2098091211 cites W1983991725 @default.
• W2098091211 cites W1984472719 @default.
• W2098091211 cites W1991804383 @default.
• W2098091211 cites W1993762151 @default.
• W2098091211 cites W2000055923 @default.
• W2098091211 cites W2013374675 @default.
• W2098091211 cites W2014275284 @default.
• W2098091211 cites W2019542254 @default.
• W2098091211 cites W2024152394 @default.
• W2098091211 cites W2028459337 @default.
• W2098091211 cites W2031468048 @default.
• W2098091211 cites W2034602546 @default.
• W2098091211 cites W2046679677 @default.
• W2098091211 cites W2048748664 @default.
• W2098091211 cites W2054771663 @default.
• W2098091211 cites W2058771734 @default.
• W2098091211 cites W2059278369 @default.
• W2098091211 cites W2084884460 @default.
• W2098091211 cites W2085956026 @default.
• W2098091211 cites W2117288567 @default.
• W2098091211 cites W2126003951 @default.
• W2098091211 cites W2137661093 @default.
• W2098091211 cites W2146165316 @default.
• W2098091211 cites W2147540551 @default.
• W2098091211 cites W2181160020 @default.
• W2098091211 cites W2332188677 @default.
• W2098091211 cites W2411755541 @default.
• W2098091211 cites W2416396204 @default.
• W2098091211 cites W2435941966 @default.
• W2098091211 cites W32329745 @default.
• W2098091211 cites W60817660 @default.
• W2098091211 doi "https://doi.org/10.1093/toxsci/51.1.9" @default.
• W2098091211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10496673" @default.
• W2098091211 hasPublicationYear "1999" @default.
• W2098091211 type Work @default.
• W2098091211 sameAs 2098091211 @default.
• W2098091211 citedByCount "35" @default.
• W2098091211 countsByYear W20980912112012 @default.
• W2098091211 countsByYear W20980912112013 @default.
• W2098091211 countsByYear W20980912112014 @default.
• W2098091211 countsByYear W20980912112015 @default.
• W2098091211 countsByYear W20980912112016 @default.
• W2098091211 countsByYear W20980912112017 @default.
• W2098091211 countsByYear W20980912112018 @default.
• W2098091211 countsByYear W20980912112021 @default.
• W2098091211 countsByYear W20980912112023 @default.
• W2098091211 crossrefType "journal-article" @default.
• W2098091211 hasAuthorship W2098091211A5009606299 @default.
• W2098091211 hasAuthorship W2098091211A5033969852 @default.
• W2098091211 hasAuthorship W2098091211A5035581331 @default.
• W2098091211 hasAuthorship W2098091211A5068467304 @default.
• W2098091211 hasAuthorship W2098091211A5082605513 @default.
• W2098091211 hasAuthorship W2098091211A5087511546 @default.
• W2098091211 hasBestOaLocation W20980912111 @default.
• W2098091211 hasConcept C126322002 @default.
• W2098091211 hasConcept C134018914 @default.
• W2098091211 hasConcept C159167319 @default.
• W2098091211 hasConcept C204232928 @default.
• W2098091211 hasConcept C2775894120 @default.
• W2098091211 hasConcept C2776804559 @default.
• W2098091211 hasConcept C2776940978 @default.
• W2098091211 hasConcept C2777562237 @default.
• W2098091211 hasConcept C2777597313 @default.
• W2098091211 hasConcept C2778260397 @default.
• W2098091211 hasConcept C2779546955 @default.
• W2098091211 hasConcept C2780910648 @default.
• W2098091211 hasConcept C513476851 @default.
• W2098091211 hasConcept C71924100 @default.
• W2098091211 hasConcept C86803240 @default.
• W2098091211 hasConceptScore W2098091211C126322002 @default.
• W2098091211 hasConceptScore W2098091211C134018914 @default.
• W2098091211 hasConceptScore W2098091211C159167319 @default.
• W2098091211 hasConceptScore W2098091211C204232928 @default.
• W2098091211 hasConceptScore W2098091211C2775894120 @default.
• W2098091211 hasConceptScore W2098091211C2776804559 @default.
• W2098091211 hasConceptScore W2098091211C2776940978 @default.
• W2098091211 hasConceptScore W2098091211C2777562237 @default.
• W2098091211 hasConceptScore W2098091211C2777597313 @default.

• next