Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098103118> ?p ?o ?g. }
- W2098103118 endingPage "898" @default.
- W2098103118 startingPage "898" @default.
- W2098103118 abstract "Yohimbine, an alpha 2-adrenergic receptor antagonist that increases noradrenergic function, was administered to 16 healthy subjects and 18 drug-free schizophrenic patients with (n = 10) and without (n = 8) tardive dyskinesia (TD). Outcome measures of this double-blind, placebo-controlled study included changes in behavior, plasma 3-methoxy-4-hydroxy-phenylglycol (MHPG) level, blood pressure, and heart rate. A subgroup of six patients experienced a notable dysphoric arousal reaction that occurred 60 to 90 minutes following administration of 20 mg of yohimbine, this reaction was not observed in healthy subjects. The schizophrenic group as a whole (not the subgroup) showed a statistical trend toward a greater yohimbine-induced increase in plasma MHPG level and systolic sitting blood pressure. The patients with TD did not differ from those without TD or from healthy controls in their response to yohimbine. These results do not support the hypothesis that noradrenergic dysfunction plays a strong central role in the pathogenesis of schizophrenia or TD. However, further studies of noradrenergic dysfunction in sub-groups of patients with schizophrenia are indicated." @default.
- W2098103118 created "2016-06-24" @default.
- W2098103118 creator A5078109250 @default.
- W2098103118 date "1987-10-01" @default.
- W2098103118 modified "2023-09-23" @default.
- W2098103118 title "Noradrenergic Function in Schizophrenia" @default.
- W2098103118 cites W106107962 @default.
- W2098103118 cites W1652867089 @default.
- W2098103118 cites W1757887121 @default.
- W2098103118 cites W1763860198 @default.
- W2098103118 cites W182683816 @default.
- W2098103118 cites W1970951836 @default.
- W2098103118 cites W1971280977 @default.
- W2098103118 cites W1974702488 @default.
- W2098103118 cites W1980636000 @default.
- W2098103118 cites W1981112641 @default.
- W2098103118 cites W1984593818 @default.
- W2098103118 cites W1998089591 @default.
- W2098103118 cites W2004397445 @default.
- W2098103118 cites W2005810309 @default.
- W2098103118 cites W2016209500 @default.
- W2098103118 cites W2019052063 @default.
- W2098103118 cites W2020844317 @default.
- W2098103118 cites W2021241599 @default.
- W2098103118 cites W2027951358 @default.
- W2098103118 cites W2033384960 @default.
- W2098103118 cites W2035157434 @default.
- W2098103118 cites W2041261226 @default.
- W2098103118 cites W2053649037 @default.
- W2098103118 cites W2055225853 @default.
- W2098103118 cites W2059219658 @default.
- W2098103118 cites W2061847572 @default.
- W2098103118 cites W2069757353 @default.
- W2098103118 cites W2070156419 @default.
- W2098103118 cites W2073998323 @default.
- W2098103118 cites W2077373876 @default.
- W2098103118 cites W2080627017 @default.
- W2098103118 cites W2091854264 @default.
- W2098103118 cites W2120971328 @default.
- W2098103118 cites W2125738714 @default.
- W2098103118 cites W2144461896 @default.
- W2098103118 cites W2159802734 @default.
- W2098103118 cites W2163949972 @default.
- W2098103118 cites W2167997573 @default.
- W2098103118 cites W2395107770 @default.
- W2098103118 cites W2396121385 @default.
- W2098103118 cites W2398146976 @default.
- W2098103118 cites W2400043587 @default.
- W2098103118 cites W2408224099 @default.
- W2098103118 cites W2412964889 @default.
- W2098103118 cites W2415488149 @default.
- W2098103118 cites W2417059513 @default.
- W2098103118 cites W2426997731 @default.
- W2098103118 cites W2433159134 @default.
- W2098103118 cites W306135330 @default.
- W2098103118 cites W648464267 @default.
- W2098103118 cites W8883528 @default.
- W2098103118 cites W93989563 @default.
- W2098103118 cites W2143230812 @default.
- W2098103118 cites W2624944499 @default.
- W2098103118 doi "https://doi.org/10.1001/archpsyc.1987.01800220068010" @default.
- W2098103118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3662745" @default.
- W2098103118 hasPublicationYear "1987" @default.
- W2098103118 type Work @default.
- W2098103118 sameAs 2098103118 @default.
- W2098103118 citedByCount "30" @default.
- W2098103118 countsByYear W20981031182014 @default.
- W2098103118 countsByYear W20981031182017 @default.
- W2098103118 crossrefType "journal-article" @default.
- W2098103118 hasAuthorship W2098103118A5078109250 @default.
- W2098103118 hasConcept C118552586 @default.
- W2098103118 hasConcept C126322002 @default.
- W2098103118 hasConcept C134018914 @default.
- W2098103118 hasConcept C142724271 @default.
- W2098103118 hasConcept C15744967 @default.
- W2098103118 hasConcept C164705383 @default.
- W2098103118 hasConcept C169760540 @default.
- W2098103118 hasConcept C170493617 @default.
- W2098103118 hasConcept C204787440 @default.
- W2098103118 hasConcept C27081682 @default.
- W2098103118 hasConcept C2776412080 @default.
- W2098103118 hasConcept C2776885963 @default.
- W2098103118 hasConcept C2777676773 @default.
- W2098103118 hasConcept C2777953023 @default.
- W2098103118 hasConcept C2778514916 @default.
- W2098103118 hasConcept C2779158372 @default.
- W2098103118 hasConcept C36951298 @default.
- W2098103118 hasConcept C42219234 @default.
- W2098103118 hasConcept C513476851 @default.
- W2098103118 hasConcept C71924100 @default.
- W2098103118 hasConcept C84393581 @default.
- W2098103118 hasConceptScore W2098103118C118552586 @default.
- W2098103118 hasConceptScore W2098103118C126322002 @default.
- W2098103118 hasConceptScore W2098103118C134018914 @default.
- W2098103118 hasConceptScore W2098103118C142724271 @default.
- W2098103118 hasConceptScore W2098103118C15744967 @default.
- W2098103118 hasConceptScore W2098103118C164705383 @default.
- W2098103118 hasConceptScore W2098103118C169760540 @default.