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• W2098109055 abstract "An intense fear of abandonment or rejection is a central feature of social relationships for individuals with borderline personality disorder (BPD). A total of 20 unmedicated BPD patients and 20 healthy participants (HC, matched for age and education) played a virtual ball-tossing game including the three conditions: exclusion, inclusion and a control condition with predefined game rules, whereas cerebral activity was assessed using functional magnetic resonance imaging. Subjective experiences of exclusion were assessed after each blocked condition. Both groups felt similarly excluded during the exclusion condition; however, BPD subjects felt more excluded than HC during the inclusion and control conditions. In all three conditions, BPD patients showed a stronger engagement of the dorsal anterior cingulate and medial prefrontal cortex. For HC, activation in several cerebral regions such as the insula and the precuneus differed depending on the interaction situation, whereas for BPD subjects activation in these regions was not modulated by experimental conditions. Subjects with BPD differed from HC in both their subjective reactions to and their neural processing of social interaction situations. Our data suggest that individuals with BPD have difficulty in discriminating between social situations, and tend to hypermentalize during social encounters that are not determined by the intentions of others." @default.
• W2098109055 created "2016-06-24" @default.
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• W2098109055 date "2013-11-21" @default.
• W2098109055 modified "2023-10-06" @default.
• W2098109055 title "Cerebral processing of social rejection in patients with borderline personality disorder" @default.
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• W2098109055 doi "https://doi.org/10.1093/scan/nst176" @default.
• W2098109055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4221221" @default.
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