FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098119630> ?p ?o ?g. }

• W2098119630 endingPage "3429" @default.
• W2098119630 startingPage "3420" @default.
• W2098119630 abstract "The surface lipoproteins of the Lyme disease spirochaete Borrelia burgdorferi directly interact with tissue microenvironments during mammalian infection, and thus potentially affect various aspects of infection. To investigate the influence of surface antigen synthesis on infectious behaviour, B. burgdorferi was modified to constitutively produce the well-characterized surface lipoproteins OspA and invariant VlsE. Although increasing OspA or VlsE production did not significantly affect synthesis of other surface lipoproteins or spirochaetal growth in vitro, overexpressing vlsE resulted in increased ospA but decreased ospC expression, and overexpressing ospA led to decreased ospC and vlsE expression in severe combined immunodeficient (SCID) mice. Increasing the expression of either ospA or vlsE did not alter the ID(50), but affected spirochaetal dissemination and significantly reduced tissue spirochaete loads in SCID mice. In immunocompetent mice, increased vlsE expression resulted in quick clearance of infection, while constitutive ospA expression led to a substantial ID(50) increase and severely impaired dissemination. Furthermore, B. burgdorferi with constitutive ospA expression persisted in the skin tissue but was cleared from both heart and joints of chronically infected immunocompetent mice. Taken together, the study indicates that increasing production of OspA or invariant VlsE influences lipoprotein gene expression in the murine host and alters the infectious behaviour of B. burgdorferi." @default.
• W2098119630 created "2016-06-24" @default.
• W2098119630 creator A5018334633 @default.
• W2098119630 creator A5037956347 @default.
• W2098119630 creator A5051894640 @default.
• W2098119630 date "2008-11-01" @default.
• W2098119630 modified "2023-10-16" @default.
• W2098119630 title "Modification of Borrelia burgdorferi to overproduce OspA or VlsE alters its infectious behaviour" @default.
• W2098119630 cites W1499069904 @default.
• W2098119630 cites W1559018846 @default.
• W2098119630 cites W1645200692 @default.
• W2098119630 cites W1949825747 @default.
• W2098119630 cites W1977904572 @default.
• W2098119630 cites W1980173932 @default.
• W2098119630 cites W1986984168 @default.
• W2098119630 cites W1993249060 @default.
• W2098119630 cites W2012706326 @default.
• W2098119630 cites W2015430118 @default.
• W2098119630 cites W2019962465 @default.
• W2098119630 cites W2029103031 @default.
• W2098119630 cites W2034165249 @default.
• W2098119630 cites W2043321476 @default.
• W2098119630 cites W2047283050 @default.
• W2098119630 cites W2062364913 @default.
• W2098119630 cites W2067085675 @default.
• W2098119630 cites W2076096086 @default.
• W2098119630 cites W2087194666 @default.
• W2098119630 cites W2097676739 @default.
• W2098119630 cites W2101640708 @default.
• W2098119630 cites W2102266633 @default.
• W2098119630 cites W2105109145 @default.
• W2098119630 cites W2113896734 @default.
• W2098119630 cites W2117557725 @default.
• W2098119630 cites W2117879359 @default.
• W2098119630 cites W2121072694 @default.
• W2098119630 cites W2121386707 @default.
• W2098119630 cites W2122860405 @default.
• W2098119630 cites W2123757128 @default.
• W2098119630 cites W2125041433 @default.
• W2098119630 cites W2125811166 @default.
• W2098119630 cites W2129892588 @default.
• W2098119630 cites W2139168909 @default.
• W2098119630 cites W2141223996 @default.
• W2098119630 cites W2143329373 @default.
• W2098119630 cites W2156198285 @default.
• W2098119630 cites W2160384143 @default.
• W2098119630 cites W2160953240 @default.
• W2098119630 cites W2166361383 @default.
• W2098119630 cites W2169075544 @default.
• W2098119630 cites W4229726285 @default.
• W2098119630 doi "https://doi.org/10.1099/mic.0.2008/019737-0" @default.
• W2098119630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18957595" @default.
• W2098119630 hasPublicationYear "2008" @default.
• W2098119630 type Work @default.
• W2098119630 sameAs 2098119630 @default.
• W2098119630 citedByCount "19" @default.
• W2098119630 countsByYear W20981196302013 @default.
• W2098119630 countsByYear W20981196302014 @default.
• W2098119630 countsByYear W20981196302015 @default.
• W2098119630 countsByYear W20981196302016 @default.
• W2098119630 crossrefType "journal-article" @default.
• W2098119630 hasAuthorship W2098119630A5018334633 @default.
• W2098119630 hasAuthorship W2098119630A5037956347 @default.
• W2098119630 hasAuthorship W2098119630A5051894640 @default.
• W2098119630 hasBestOaLocation W20981196301 @default.
• W2098119630 hasConcept C147483822 @default.
• W2098119630 hasConcept C159047783 @default.
• W2098119630 hasConcept C159654299 @default.
• W2098119630 hasConcept C203014093 @default.
• W2098119630 hasConcept C2777553296 @default.
• W2098119630 hasConcept C2779159148 @default.
• W2098119630 hasConcept C2779553505 @default.
• W2098119630 hasConcept C2908660692 @default.
• W2098119630 hasConcept C86803240 @default.
• W2098119630 hasConcept C89423630 @default.
• W2098119630 hasConceptScore W2098119630C147483822 @default.
• W2098119630 hasConceptScore W2098119630C159047783 @default.
• W2098119630 hasConceptScore W2098119630C159654299 @default.
• W2098119630 hasConceptScore W2098119630C203014093 @default.
• W2098119630 hasConceptScore W2098119630C2777553296 @default.
• W2098119630 hasConceptScore W2098119630C2779159148 @default.
• W2098119630 hasConceptScore W2098119630C2779553505 @default.
• W2098119630 hasConceptScore W2098119630C2908660692 @default.
• W2098119630 hasConceptScore W2098119630C86803240 @default.
• W2098119630 hasConceptScore W2098119630C89423630 @default.
• W2098119630 hasIssue "11" @default.
• W2098119630 hasLocation W20981196301 @default.
• W2098119630 hasLocation W20981196302 @default.
• W2098119630 hasOpenAccess W2098119630 @default.
• W2098119630 hasPrimaryLocation W20981196301 @default.
• W2098119630 hasRelatedWork W2022178101 @default.
• W2098119630 hasRelatedWork W2027226830 @default.
• W2098119630 hasRelatedWork W2130748494 @default.
• W2098119630 hasRelatedWork W2143274099 @default.
• W2098119630 hasRelatedWork W2149023602 @default.
• W2098119630 hasRelatedWork W2168718741 @default.
• W2098119630 hasRelatedWork W2170167886 @default.
• W2098119630 hasRelatedWork W2379129879 @default.

• next