FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098126839> ?p ?o ?g. }

• W2098126839 endingPage "8339" @default.
• W2098126839 startingPage "8332" @default.
• W2098126839 abstract "ABSTRACT VSV-FH is a hybrid vesicular stomatitis virus (VSV) with a deletion of its G glycoprotein and encoding the measles virus (MV) fusion (F) and hemagglutinin (H) envelope glycoproteins. VSV-FH infects cells expressing MV receptors and is fusogenic and effective against myeloma xenografts in mice. We evaluated the fusogenic activities of MV and VSV-FH in relationship to the density of receptor on the target cell surface and the kinetics of F and H expression in infected cells. Using a panel of cells expressing increasing numbers of the MV receptor CD46, we evaluated syncytium size in MV- or VSV-FH-infected cells. VSV-FH is not fusogenic at low CD46 density but requires less CD46 for syncytium formation than MV. The size of each syncytium is larger in VSV-FH-infected cells at a specific CD46 density. While syncytium size reached a plateau and did not increase further in MV-infected CHO cells expressing ≥4,620 CD46 copies/cell, there was a corresponding increase in syncytium size with increases in CD46 levels in VSV-FH-infected CD46-expressing CHO (CHO-CD46) cells. Further analysis in VSV-FH-infected cell lines shows earlier and higher expression of F and H mRNAs and protein. However, VSV-FH cytotoxic activity was reduced by pretreatment of the cells with type I interferon. In contrast, the cytopathic effects are not affected in MV-infected cells. In summary, VSV-FH has significant advantages over MV as an oncolytic virus due to its higher viral yield, faster replication kinetics, and larger fusogenic capabilities but should be used in cancer types with defective interferon signaling pathways. IMPORTANCE We studied the cytotoxic activity of a vesicular stomatitis/measles hybrid virus (VSV-FH), which is superior to that of measles virus (MV), in different cancer cell lines. We determined that viral RNA and protein were produced faster and in higher quantities in VSV-FH-infected cells. This resulted in the formation of larger syncytia, higher production of infectious particles, and a more potent cytopathic effect in permissive cells. Importantly, VSV-FH, similar to MV, can discriminate between low- and high-expressing CD46 cells, a phenotype important for cancer therapy as the virus will be able to preferentially infect cancer cells that overexpress CD46 over low-CD46-expressing normal cells." @default.
• W2098126839 created "2016-06-24" @default.
• W2098126839 creator A5023644310 @default.
• W2098126839 creator A5051470930 @default.
• W2098126839 creator A5080599250 @default.
• W2098126839 creator A5088371291 @default.
• W2098126839 date "2014-08-01" @default.
• W2098126839 modified "2023-10-15" @default.
• W2098126839 title "Faster Replication and Higher Expression Levels of Viral Glycoproteins Give the Vesicular Stomatitis Virus/Measles Virus Hybrid VSV-FH a Growth Advantage over Measles Virus" @default.
• W2098126839 cites W1590690028 @default.
• W2098126839 cites W1591890160 @default.
• W2098126839 cites W1606607050 @default.
• W2098126839 cites W1845094941 @default.
• W2098126839 cites W1966044017 @default.
• W2098126839 cites W1975723973 @default.
• W2098126839 cites W2007129787 @default.
• W2098126839 cites W2032954528 @default.
• W2098126839 cites W2033966423 @default.
• W2098126839 cites W2034901529 @default.
• W2098126839 cites W2035973356 @default.
• W2098126839 cites W2039635444 @default.
• W2098126839 cites W2042288895 @default.
• W2098126839 cites W2044565334 @default.
• W2098126839 cites W2046461758 @default.
• W2098126839 cites W2057913071 @default.
• W2098126839 cites W2059519404 @default.
• W2098126839 cites W2061869265 @default.
• W2098126839 cites W2066877940 @default.
• W2098126839 cites W2067847775 @default.
• W2098126839 cites W2073215113 @default.
• W2098126839 cites W2079267696 @default.
• W2098126839 cites W2079814213 @default.
• W2098126839 cites W2082215826 @default.
• W2098126839 cites W2087365471 @default.
• W2098126839 cites W2099540110 @default.
• W2098126839 cites W2102125033 @default.
• W2098126839 cites W2102883003 @default.
• W2098126839 cites W2117154097 @default.
• W2098126839 cites W2120268906 @default.
• W2098126839 cites W2129818141 @default.
• W2098126839 cites W2140997748 @default.
• W2098126839 cites W2148060514 @default.
• W2098126839 doi "https://doi.org/10.1128/jvi.03823-13" @default.
• W2098126839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4135973" @default.
• W2098126839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24829351" @default.
• W2098126839 hasPublicationYear "2014" @default.
• W2098126839 type Work @default.
• W2098126839 sameAs 2098126839 @default.
• W2098126839 citedByCount "25" @default.
• W2098126839 countsByYear W20981268392015 @default.
• W2098126839 countsByYear W20981268392016 @default.
• W2098126839 countsByYear W20981268392017 @default.
• W2098126839 countsByYear W20981268392018 @default.
• W2098126839 countsByYear W20981268392019 @default.
• W2098126839 countsByYear W20981268392020 @default.
• W2098126839 countsByYear W20981268392021 @default.
• W2098126839 countsByYear W20981268392022 @default.
• W2098126839 crossrefType "journal-article" @default.
• W2098126839 hasAuthorship W2098126839A5023644310 @default.
• W2098126839 hasAuthorship W2098126839A5051470930 @default.
• W2098126839 hasAuthorship W2098126839A5080599250 @default.
• W2098126839 hasAuthorship W2098126839A5088371291 @default.
• W2098126839 hasBestOaLocation W20981268391 @default.
• W2098126839 hasConcept C108625454 @default.
• W2098126839 hasConcept C140704245 @default.
• W2098126839 hasConcept C153911025 @default.
• W2098126839 hasConcept C159047783 @default.
• W2098126839 hasConcept C22070199 @default.
• W2098126839 hasConcept C2522874641 @default.
• W2098126839 hasConcept C2776438120 @default.
• W2098126839 hasConcept C2777974785 @default.
• W2098126839 hasConcept C2778199166 @default.
• W2098126839 hasConcept C2779057330 @default.
• W2098126839 hasConcept C2780355102 @default.
• W2098126839 hasConcept C2780727368 @default.
• W2098126839 hasConcept C2780813555 @default.
• W2098126839 hasConcept C40479148 @default.
• W2098126839 hasConcept C54355233 @default.
• W2098126839 hasConcept C81885089 @default.
• W2098126839 hasConcept C82210918 @default.
• W2098126839 hasConcept C86803240 @default.
• W2098126839 hasConcept C92488253 @default.
• W2098126839 hasConcept C97380033 @default.
• W2098126839 hasConceptScore W2098126839C108625454 @default.
• W2098126839 hasConceptScore W2098126839C140704245 @default.
• W2098126839 hasConceptScore W2098126839C153911025 @default.
• W2098126839 hasConceptScore W2098126839C159047783 @default.
• W2098126839 hasConceptScore W2098126839C22070199 @default.
• W2098126839 hasConceptScore W2098126839C2522874641 @default.
• W2098126839 hasConceptScore W2098126839C2776438120 @default.
• W2098126839 hasConceptScore W2098126839C2777974785 @default.
• W2098126839 hasConceptScore W2098126839C2778199166 @default.
• W2098126839 hasConceptScore W2098126839C2779057330 @default.
• W2098126839 hasConceptScore W2098126839C2780355102 @default.
• W2098126839 hasConceptScore W2098126839C2780727368 @default.
• W2098126839 hasConceptScore W2098126839C2780813555 @default.
• W2098126839 hasConceptScore W2098126839C40479148 @default.
• W2098126839 hasConceptScore W2098126839C54355233 @default.

• next