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• W2098147597 abstract "Von Willebrand pigs have all the manifestations of the severe human disease. The role of Willebrand antigen (VIII R:AG) and ristocetin cofactor (VIII: RWF) was assessed in these pigs by (1) transfusion and (2) in vitro bleeding time assay. The skin bleeding time became normal when the level of transfused Willebrand factor (VIII R:AG/RWF) was raised in the plasma above 30 U/dl. After single or repeated transfusions, skin capillary endothelium and platelets were still distinguished from normal by VIII R:AG deficiency. When incisions in excised porcine skin (in vitro bleeding time) were perfused with blood and plasma fractions, haemostasis occurred when plasmatic Willebrand factor exceeded 30 U/dl whether the skin or platelets came from normal or from von Willebrand pigs. The platelet plug occluding the skin incision contained VIII R:AG by immunofluorescence. Willebrand factor appears to coat surfaces and to serve as a platelet attachment protein. These bleeder pigs are resistant to atherosclerosis. If platelets are involved in early atherosclerotic lesions, the role of Willebrand factor in platelet - blood vessel interaction may be important." @default.
• W2098147597 created "2016-06-24" @default.
• W2098147597 date "1981-08-18" @default.
• W2098147597 modified "2023-09-26" @default.
• W2098147597 title "The role of Willebrand factor in platelet — blood vessel interaction, including a discussion of resistance to atherosclerosis in pigs with von Willebrand’s disease" @default.
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• W2098147597 doi "https://doi.org/10.1098/rstb.1981.0105" @default.
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