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- W2098174216 abstract "Chronic myeloid leukemia (CML) is characterized by formation of theBCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. Large deletions on the derivative chromosome 9 have recently been reported, but it was unclear whether deletions arose during disease progression or at the time of the Ph translocation. Fluorescence in situ hybridization (FISH) analysis was used to assess the deletion status of 253 patients with CML. The strength of deletion status as a prognostic indicator was then compared to the Sokal and Hasford scoring systems. The frequency of deletions was similar at diagnosis and after disease progression but was significantly increased in patients with variant Ph translocations. In patients with a deletion, all Ph+metaphases carried the deletion. The median survival of patients with and without deletions was 38 months and 88 months, respectively (P = .0001). By contrast the survival difference between Sokal or Hasford high-risk and non–high-risk patients was of only borderline significance (P = .057 andP = .034). The results indicate that deletions occur at the time of the Ph translocation. An apparently simple reciprocal translocation may therefore result in considerable genetic heterogeneity ab initio, a concept that is likely to apply to other malignancies associated with translocations. Deletion status is also a powerful and independent prognostic factor for patients with CML. The prognostic significance of deletion status should now be studied prospectively and, if confirmed, should be incorporated into management decisions and the analysis of clinical trials. Subjects: Clinical Trials and Observations, Neoplasia Topics: chromosomes, human, pair 9, leukemia, myelocytic, chronic, translocation (genetics), bcr-abl tyrosine kinase, prognostic factors, fluorescent in situ hybridization, disease progression, cancer" @default.
- W2098174216 created "2016-06-24" @default.
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- W2098174216 date "2001-09-15" @default.
- W2098174216 modified "2023-09-27" @default.
- W2098174216 title "Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia" @default.
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- W2098174216 cites W1576499394 @default.
- W2098174216 cites W1601865173 @default.
- W2098174216 cites W1780815163 @default.
- W2098174216 cites W1799579309 @default.
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- W2098174216 cites W2337277825 @default.
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- W2098174216 doi "https://doi.org/10.1182/blood.v98.6.1732" @default.
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