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- W2098184993 abstract "Nerve growth factor (NGF) is one of the well characterized regulators of galanin expression. NGF deprivation can induce galanin expression in dorsal root ganglion (DRG) neurons. Galanin is recognized as one of the DRG injury markers. Norepinephrine (NE) activates alpha-adrenoreceptors usually expressed in sympathetic neuronal membrane. It has been shown that functional alpha-adrenoreceptors are also expressed in primary sensory neurons. Whether NGF association with NE influences the galanin expression in DRG neurons remains unknown. In the present study, we have evaluated the possible regulation of galanin mRNA or galanin peptide expression by co-administration of NGF and NE in primary cultures of rat DRG neurons. After four days incubation with NGF and/or NE in primary cultures of rat DRG neurons, NGF inhibited and NE promoted galanin mRNA and galanin peptide expression as compared with that in control DRG neuron cultures at the same time point. NGF also inhibited the elevation of galanin expression indu..." @default.
- W2098184993 created "2016-06-24" @default.
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- W2098184993 date "2009-06-22" @default.
- W2098184993 modified "2023-09-24" @default.
- W2098184993 title "Nerve growth factor and norepinephrine regulate galanin expression in primary cultures of dorsal root ganglion neurons" @default.
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- W2098184993 doi "https://doi.org/10.1080/13880200902915630" @default.
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