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- W2098191504 abstract "Baroreflex sensitivity was assessed in 9 normotensive (N), 8 renal wrap (one kidney model, RH) and 16 medial sclerotic rabbits (MS, fed on calciferol 50,000 i.u. and calcium lactate 1g for 10 days) before (mean 8P;N, 79±3.3 mm Hg; RH, 80±7.4 mm Hg; and MS, 83±1.0 mm Hg) and at monthly intervals for up to 16 weeks after the induction of the disease processes (mean 8P;N, 87±3.9 mm Hg; RH, 127±7.2 mm Hg and MS, 99±3.8 mm Hg). Blood pressure was elevated by i.v. phenylephrine (5 and 10 μg.kg−1) or angiotensin (250 ng.kg−1) and baroreflex sensitivity assessed by the increase of pulse interval per unit rise of pressure. The pressor response was greater in the RH and MS than in the N rabbits. The baroreflex sensitivity showed a progressive reduction with time and with the elevation of blood pressure in both MS and RH rabbits. The difference was significantly greater (P<0.01) than in the aged related control rabbits (P>0.05). There was an inverse relationship between baroreflex sensitivity and the pressor response in MS rabbits. Results indicated progressive barorecptors dysfunction i n hypertensive and medial sclerotic rabbits." @default.
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- W2098191504 date "1980-01-01" @default.
- W2098191504 modified "2023-09-27" @default.
- W2098191504 title "Baroreflex Sensitivity in Rabbits During the Development of Experimental Renal Hypertension and Medial Sclerosis" @default.
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- W2098191504 doi "https://doi.org/10.3109/10641968009046427" @default.
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