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• W2098215830 abstract "Na + and K + channel-blocking drugs have anti- and proarrhythmic effects. Their effects during fibrillation, however, remain poorly understood. We used computer simulation of a two-dimensional (2-D) structurally normal tissue model with phase I of the Luo-Rudy action potential model to study the effects of Na + and K + channel blockade on vulnerability to and termination of reentry in simulated multiple-wavelet and mother rotor fibrillation. Our main findings are as follows: 1) Na + channel blockade decreased, whereas K + channel blockade increased, the vulnerable window of reentry in heterogeneous 2-D tissue because of opposing effects on dynamical wave instability. 2) Na + channel blockade increased the cycle length of reentry more than it increased refractoriness. In multiple-wavelet fibrillation, Na + channel blockade first increased and then decreased the average duration or transient time (<T s >) of fibrillation. In mother rotor fibrillation, Na + channel blockade caused peripheral fibrillatory conduction block to resolve and the mother rotor to drift, leading to self-termination or sustained tachycardia. 3) K + channel blockade increased dynamical instability by steepening action potential duration restitution. In multiple-wavelet fibrillation, this effect shortened <T s > because of enhanced wave instability. In mother rotor fibrillation, this effect converted mother rotor fibrillation to multiple-wavelet fibrillation, which then could self-terminate. Our findings help illuminate, from a theoretical perspective, the possible underlying mechanisms of termination of different types of fibrillation by antiarrhythmic drugs." @default.
• W2098215830 created "2016-06-24" @default.
• W2098215830 creator A5009561014 @default.
• W2098215830 creator A5051699207 @default.
• W2098215830 date "2005-10-01" @default.
• W2098215830 modified "2023-10-14" @default.
• W2098215830 title "Effects of Na⁺ and K⁺ channel blockade on vulnerability to and termination of fibrillation in simulated normal cardiac tissue" @default.
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• W2098215830 doi "https://doi.org/10.1152/ajpheart.00241.2005" @default.
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