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- W2098217243 abstract "ABSTRACT T-cell proliferative responses were studied in two villages in Gabon with different levels of Loa loa transmission. The first village (Okoumbi) had an annual transmission potential (ATP) of ≈9,000 infective larvae (L3)/person/year (high transmission village), while the second village (Ndjokaye) had an ATP of ≈1,000 L3/person/year (low transmission village). Proliferation and cytokine assays were performed on peripheral blood mononuclear cells (PBMC) from individuals aged 18 years and over using either mitogens (concanavalin A or phytohemagglutinin), antigens (purified protein derivative [PPD], irrelevant antigen), or soluble extracts of L3, microfilariae, or adult L. loa . PBMC from individuals in the low transmission village responded better to stimulation with adult antigen and to PPD than did PBMC from individuals in the high transmission village ( P = 0.0031 and P = 0.0012, respectively). These data suggest that high levels of transmission of L. loa depress both specific and nonspecific T-cell proliferative responses in infected humans." @default.
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- W2098217243 date "2002-03-01" @default.
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- W2098217243 title "Transmission Intensity Affects Both Antigen-Specific and Nonspecific T-Cell Proliferative Responses in<i>Loa loa</i>Infection" @default.
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- W2098217243 doi "https://doi.org/10.1128/iai.70.3.1475-1480.2002" @default.
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