FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098249145> ?p ?o ?g. }

• W2098249145 endingPage "8" @default.
• W2098249145 startingPage "564" @default.
• W2098249145 abstract "Cell-mediated antitumor effects have, in part, been attributed to the production of NO. Compounds which generate NO might, therefore, be useful in attenuating the growth of tumor cells. Six nitric oxide/nucleophile adducts that release NO spontaneously in solution were tested for their effectiveness in inhibiting DNA synthesis in A375 human melanoma cells. The complexes of NO with spermine, 3-(n-propylamino)propylamine (PAPA/NO), and diethylamine reduced thymidine incorporation by 50% at concentrations of 24, 44, and 128 microM, respectively. The degree of inhibition was, in general, related to the rate and extent of NO release in solution. A melanoma cell clone sensitive to interleukin 1-mediated cytostasis (A375-C6) was no more sensitive to PAPA/NO than a clone resistant to interleukin 1 (A375-C5), suggesting that the differing inhibitory effects of interleukin 1 in the two A375 cell clones are not due to a differential sensitivity to nitric oxide. Oxymyoglobin (125 microM), a known scavenger of NO, restored the ability of A375-C6 cells to incorporate thymidine in the presence of up to 200 microM PAPA/NO. When PAPA/NO was added to a solution of oxymyoglobin, nitrosylmyoglobin was formed, indicating that the protective effect of myoglobin was due to scavenging of NO. The results are consistent with a nitric oxide-mediated mechanism for NO/nucleophile cytostasis and suggest that such compounds may be useful as tools for investigating the role of reactive nitrogen intermediates in cytostasis and cytotoxicity." @default.
• W2098249145 created "2016-06-24" @default.
• W2098249145 creator A5033719482 @default.
• W2098249145 creator A5042240287 @default.
• W2098249145 creator A5051192406 @default.
• W2098249145 creator A5069348197 @default.
• W2098249145 creator A5075003658 @default.
• W2098249145 date "1993-02-01" @default.
• W2098249145 modified "2023-10-17" @default.
• W2098249145 title "Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release." @default.
• W2098249145 cites W1479917310 @default.
• W2098249145 cites W1514954818 @default.
• W2098249145 cites W1525976258 @default.
• W2098249145 cites W1532989721 @default.
• W2098249145 cites W1585714318 @default.
• W2098249145 cites W1590691993 @default.
• W2098249145 cites W1602254368 @default.
• W2098249145 cites W1929009802 @default.
• W2098249145 cites W1967315269 @default.
• W2098249145 cites W1972845367 @default.
• W2098249145 cites W1978234307 @default.
• W2098249145 cites W1979230311 @default.
• W2098249145 cites W1987165240 @default.
• W2098249145 cites W1988726352 @default.
• W2098249145 cites W1994303699 @default.
• W2098249145 cites W1994389040 @default.
• W2098249145 cites W1996003434 @default.
• W2098249145 cites W1998879311 @default.
• W2098249145 cites W2010374269 @default.
• W2098249145 cites W2017844141 @default.
• W2098249145 cites W2023772557 @default.
• W2098249145 cites W2025334605 @default.
• W2098249145 cites W2026155860 @default.
• W2098249145 cites W2038148658 @default.
• W2098249145 cites W2073132923 @default.
• W2098249145 cites W2078865702 @default.
• W2098249145 cites W2082408832 @default.
• W2098249145 cites W2094746732 @default.
• W2098249145 cites W2094860903 @default.
• W2098249145 cites W2102838769 @default.
• W2098249145 cites W2143612963 @default.
• W2098249145 cites W2145555194 @default.
• W2098249145 cites W2153491246 @default.
• W2098249145 cites W2409875105 @default.
• W2098249145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8425188" @default.
• W2098249145 hasPublicationYear "1993" @default.
• W2098249145 type Work @default.
• W2098249145 sameAs 2098249145 @default.
• W2098249145 citedByCount "47" @default.
• W2098249145 countsByYear W20982491452012 @default.
• W2098249145 countsByYear W20982491452013 @default.
• W2098249145 countsByYear W20982491452014 @default.
• W2098249145 countsByYear W20982491452016 @default.
• W2098249145 countsByYear W20982491452017 @default.
• W2098249145 countsByYear W20982491452018 @default.
• W2098249145 countsByYear W20982491452020 @default.
• W2098249145 crossrefType "journal-article" @default.
• W2098249145 hasAuthorship W2098249145A5033719482 @default.
• W2098249145 hasAuthorship W2098249145A5042240287 @default.
• W2098249145 hasAuthorship W2098249145A5051192406 @default.
• W2098249145 hasAuthorship W2098249145A5069348197 @default.
• W2098249145 hasAuthorship W2098249145A5075003658 @default.
• W2098249145 hasConcept C109316439 @default.
• W2098249145 hasConcept C178790620 @default.
• W2098249145 hasConcept C182547069 @default.
• W2098249145 hasConcept C185592680 @default.
• W2098249145 hasConcept C202751555 @default.
• W2098249145 hasConcept C2777658100 @default.
• W2098249145 hasConcept C502942594 @default.
• W2098249145 hasConcept C519581460 @default.
• W2098249145 hasConcept C55493867 @default.
• W2098249145 hasConcept C86803240 @default.
• W2098249145 hasConceptScore W2098249145C109316439 @default.
• W2098249145 hasConceptScore W2098249145C178790620 @default.
• W2098249145 hasConceptScore W2098249145C182547069 @default.
• W2098249145 hasConceptScore W2098249145C185592680 @default.
• W2098249145 hasConceptScore W2098249145C202751555 @default.
• W2098249145 hasConceptScore W2098249145C2777658100 @default.
• W2098249145 hasConceptScore W2098249145C502942594 @default.
• W2098249145 hasConceptScore W2098249145C519581460 @default.
• W2098249145 hasConceptScore W2098249145C55493867 @default.
• W2098249145 hasConceptScore W2098249145C86803240 @default.
• W2098249145 hasIssue "3" @default.
• W2098249145 hasLocation W20982491451 @default.
• W2098249145 hasOpenAccess W2098249145 @default.
• W2098249145 hasPrimaryLocation W20982491451 @default.
• W2098249145 hasRelatedWork W136700406 @default.
• W2098249145 hasRelatedWork W138251835 @default.
• W2098249145 hasRelatedWork W1982232067 @default.
• W2098249145 hasRelatedWork W2076598777 @default.
• W2098249145 hasRelatedWork W2441779500 @default.
• W2098249145 hasRelatedWork W2470996272 @default.
• W2098249145 hasRelatedWork W2550081472 @default.
• W2098249145 hasRelatedWork W3083175738 @default.
• W2098249145 hasRelatedWork W3207893518 @default.
• W2098249145 hasRelatedWork W4226112693 @default.
• W2098249145 hasVolume "53" @default.
• W2098249145 isParatext "false" @default.

• next