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• W2098257366 endingPage "e1003675" @default.
• W2098257366 startingPage "e1003675" @default.
• W2098257366 abstract "Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of translation in all organisms. The anticodon modification mcm5s2U34 is required for normal growth and stress resistance in yeast; mutants lacking this modification have numerous phenotypes. Mutations in the homologous human genes are linked to neurological disease. The yeast phenotypes can be ameliorated by overexpression of specific tRNAs, suggesting that the modifications are necessary for efficient translation of specific codons. We determined the in vivo ribosome distributions at single codon resolution in yeast strains lacking mcm5s2U. We found accumulations at AAA, CAA, and GAA codons, suggesting that translation is slow when these codons are in the ribosomal A site, but these changes appeared too small to affect protein output. Instead, we observed activation of the GCN4-mediated stress response by a non-canonical pathway. Thus, loss of mcm5s2U causes global effects on gene expression due to perturbation of cellular signaling." @default.
• W2098257366 created "2016-06-24" @default.
• W2098257366 creator A5022092607 @default.
• W2098257366 creator A5054745665 @default.
• W2098257366 date "2013-08-01" @default.
• W2098257366 modified "2023-10-12" @default.
• W2098257366 title "Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling" @default.
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• W2098257366 doi "https://doi.org/10.1371/journal.pgen.1003675" @default.
• W2098257366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731203" @default.
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• W2098257366 hasPublicationYear "2013" @default.
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