FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098262598> ?p ?o ?g. }

• W2098262598 abstract "The acquisition of proliferative and invasive phenotypes is considered a hallmark of neoplastic transformation; however, the underlying mechanisms are less well known. Lipid phosphate phosphatase-3 (LPP3) not only catalyzes the dephosphorylation of the bioactive lipid sphingosine-1-phosphate (S1P) to generate sphingosine but also may regulate embryonic development and angiogenesis via the Wnt pathway. The goal of this study was to determine the role of LPP3 in tumor cells.We observed increased expression of LPP3 in glioblastoma primary tumors and in U87 and U118 glioblastoma cell lines. We demonstrate that LPP3-knockdown inhibited both U87 and U118 glioblastoma cell proliferation in culture and tumor growth in xenograft assays. Biochemical experiments provided evidence that LPP3-knockdown reduced β-catenin, CYCLIN-D1, and CD133 expression, with a concomitant increase in phosphorylated β-catenin. In a converse experiment, the forced expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased β-catenin stability and CYCLIN-D1 synthesis. In contrast, elevated expression of LPP3 had no tumorigenic effects on primary cells.These results demonstrate for the first time an unexpected role of LPP3 in regulating glioblastoma progression by amplifying β-catenin and CYCLIN-D1 activities." @default.
• W2098262598 created "2016-06-24" @default.
• W2098262598 creator A5005467406 @default.
• W2098262598 creator A5021766049 @default.
• W2098262598 creator A5053538204 @default.
• W2098262598 creator A5062925952 @default.
• W2098262598 creator A5079593455 @default.
• W2098262598 date "2011-05-11" @default.
• W2098262598 modified "2023-10-17" @default.
• W2098262598 title "Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and Cyclin-D1 signaling" @default.
• W2098262598 cites W1794030813 @default.
• W2098262598 cites W1965966865 @default.
• W2098262598 cites W1975993620 @default.
• W2098262598 cites W1987554991 @default.
• W2098262598 cites W1996406984 @default.
• W2098262598 cites W2000466286 @default.
• W2098262598 cites W2016165171 @default.
• W2098262598 cites W2018175015 @default.
• W2098262598 cites W2021433993 @default.
• W2098262598 cites W2029470215 @default.
• W2098262598 cites W2032122936 @default.
• W2098262598 cites W2048202432 @default.
• W2098262598 cites W2065522237 @default.
• W2098262598 cites W2079516541 @default.
• W2098262598 cites W2081141873 @default.
• W2098262598 cites W2102717891 @default.
• W2098262598 cites W2112703519 @default.
• W2098262598 cites W2113119464 @default.
• W2098262598 cites W2125262828 @default.
• W2098262598 cites W2127430336 @default.
• W2098262598 cites W2130852323 @default.
• W2098262598 cites W2132202643 @default.
• W2098262598 cites W2137940220 @default.
• W2098262598 cites W2144546662 @default.
• W2098262598 cites W2156263183 @default.
• W2098262598 cites W4255289481 @default.
• W2098262598 doi "https://doi.org/10.1186/1476-4598-10-51" @default.
• W2098262598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3112429" @default.
• W2098262598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21569306" @default.
• W2098262598 hasPublicationYear "2011" @default.
• W2098262598 type Work @default.
• W2098262598 sameAs 2098262598 @default.
• W2098262598 citedByCount "21" @default.
• W2098262598 countsByYear W20982625982012 @default.
• W2098262598 countsByYear W20982625982013 @default.
• W2098262598 countsByYear W20982625982014 @default.
• W2098262598 countsByYear W20982625982015 @default.
• W2098262598 countsByYear W20982625982016 @default.
• W2098262598 countsByYear W20982625982017 @default.
• W2098262598 countsByYear W20982625982019 @default.
• W2098262598 countsByYear W20982625982020 @default.
• W2098262598 countsByYear W20982625982021 @default.
• W2098262598 countsByYear W20982625982022 @default.
• W2098262598 countsByYear W20982625982023 @default.
• W2098262598 crossrefType "journal-article" @default.
• W2098262598 hasAuthorship W2098262598A5005467406 @default.
• W2098262598 hasAuthorship W2098262598A5021766049 @default.
• W2098262598 hasAuthorship W2098262598A5053538204 @default.
• W2098262598 hasAuthorship W2098262598A5062925952 @default.
• W2098262598 hasAuthorship W2098262598A5079593455 @default.
• W2098262598 hasBestOaLocation W20982625981 @default.
• W2098262598 hasConcept C11960822 @default.
• W2098262598 hasConcept C128473837 @default.
• W2098262598 hasConcept C1491633281 @default.
• W2098262598 hasConcept C170493617 @default.
• W2098262598 hasConcept C178666793 @default.
• W2098262598 hasConcept C181912034 @default.
• W2098262598 hasConcept C199835354 @default.
• W2098262598 hasConcept C2776194525 @default.
• W2098262598 hasConcept C2776596873 @default.
• W2098262598 hasConcept C2778703144 @default.
• W2098262598 hasConcept C29537977 @default.
• W2098262598 hasConcept C502942594 @default.
• W2098262598 hasConcept C55493867 @default.
• W2098262598 hasConcept C62112901 @default.
• W2098262598 hasConcept C86803240 @default.
• W2098262598 hasConcept C95444343 @default.
• W2098262598 hasConceptScore W2098262598C11960822 @default.
• W2098262598 hasConceptScore W2098262598C128473837 @default.
• W2098262598 hasConceptScore W2098262598C1491633281 @default.
• W2098262598 hasConceptScore W2098262598C170493617 @default.
• W2098262598 hasConceptScore W2098262598C178666793 @default.
• W2098262598 hasConceptScore W2098262598C181912034 @default.
• W2098262598 hasConceptScore W2098262598C199835354 @default.
• W2098262598 hasConceptScore W2098262598C2776194525 @default.
• W2098262598 hasConceptScore W2098262598C2776596873 @default.
• W2098262598 hasConceptScore W2098262598C2778703144 @default.
• W2098262598 hasConceptScore W2098262598C29537977 @default.
• W2098262598 hasConceptScore W2098262598C502942594 @default.
• W2098262598 hasConceptScore W2098262598C55493867 @default.
• W2098262598 hasConceptScore W2098262598C62112901 @default.
• W2098262598 hasConceptScore W2098262598C86803240 @default.
• W2098262598 hasConceptScore W2098262598C95444343 @default.
• W2098262598 hasIssue "1" @default.
• W2098262598 hasLocation W20982625981 @default.
• W2098262598 hasLocation W20982625982 @default.
• W2098262598 hasLocation W20982625983 @default.
• W2098262598 hasLocation W20982625984 @default.
• W2098262598 hasLocation W20982625985 @default.
• W2098262598 hasOpenAccess W2098262598 @default.

• next