FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098264989> ?p ?o ?g. }

• W2098264989 endingPage "306" @default.
• W2098264989 startingPage "299" @default.
• W2098264989 abstract "The effect of insulin on intestinal Na+/K+ ATPase is till now undetermined, and it is still unclear whether insulin exerts any modulatory effect on glucose absorption by targeting the ATPase. This work attempted to address this question and to unravel the signaling pathway involved using Caco-2 cells as a model. After an overnight starvation, cells were treated with insulin in presence and absence of specific inhibitors of some known mediators. The activity of the pump was assayed by measuring the ouabain-inhibitable inorganic phosphate (Pi) released, whereas changes in its abundance were determined by western blot analysis. Insulin decreased the activity and abundance of the ATPase in a crude membrane homogenate. This effect disappeared completely upon inhibition of either phosphotidylinositol-3 kinase (PI3K) or protein kinase C (PKC), but was partially abolished when p38MAPK or MEK/ERK were inhibited separately. Activation of PKC with phorbol-12-myristate-13-acetate (PMA) imitated the effect of insulin and was not affected by inhibition of PI3K. The data suggest that PI3K and PKC are along the same pathway that branches into two separate ones involving each either p38MAP kinase or MEK/ERK. This hypothesis was confirmed by the data obtained from the treatment of Caco-2 cells with PMA, when p38MAPK and MEK/ERK were inhibited simultaneously. Concomitant inhibition of p38MAPK and MEK/ERK abrogated fully the effect of insulin, indicating that no other pathways are present in addition to the ones proposed above." @default.
• W2098264989 created "2016-06-24" @default.
• W2098264989 creator A5043019129 @default.
• W2098264989 creator A5058001992 @default.
• W2098264989 date "2011-06-20" @default.
• W2098264989 modified "2023-10-09" @default.
• W2098264989 title "Insulin targets the Na⁺/K⁺ATPase in enterocytes via PI3K, PKC, and MAPKS" @default.
• W2098264989 cites W1528368632 @default.
• W2098264989 cites W1551967741 @default.
• W2098264989 cites W1570910952 @default.
• W2098264989 cites W1712871378 @default.
• W2098264989 cites W1926696092 @default.
• W2098264989 cites W1971238278 @default.
• W2098264989 cites W1972877141 @default.
• W2098264989 cites W1974186712 @default.
• W2098264989 cites W1978798502 @default.
• W2098264989 cites W1993657069 @default.
• W2098264989 cites W1996983786 @default.
• W2098264989 cites W2006668556 @default.
• W2098264989 cites W2014348586 @default.
• W2098264989 cites W2024256437 @default.
• W2098264989 cites W2024530909 @default.
• W2098264989 cites W2026503617 @default.
• W2098264989 cites W2057126981 @default.
• W2098264989 cites W2077257042 @default.
• W2098264989 cites W2083433543 @default.
• W2098264989 cites W2089185822 @default.
• W2098264989 cites W2093069129 @default.
• W2098264989 cites W2094338116 @default.
• W2098264989 cites W2109132990 @default.
• W2098264989 cites W2124149196 @default.
• W2098264989 cites W2144529820 @default.
• W2098264989 cites W2146157811 @default.
• W2098264989 cites W2146989813 @default.
• W2098264989 cites W2152899125 @default.
• W2098264989 cites W2162542232 @default.
• W2098264989 cites W2176108082 @default.
• W2098264989 cites W2305529136 @default.
• W2098264989 cites W2339282460 @default.
• W2098264989 cites W4248424559 @default.
• W2098264989 cites W67059296 @default.
• W2098264989 doi "https://doi.org/10.3109/10799893.2011.587821" @default.
• W2098264989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21682666" @default.
• W2098264989 hasPublicationYear "2011" @default.
• W2098264989 type Work @default.
• W2098264989 sameAs 2098264989 @default.
• W2098264989 citedByCount "9" @default.
• W2098264989 countsByYear W20982649892014 @default.
• W2098264989 countsByYear W20982649892015 @default.
• W2098264989 countsByYear W20982649892016 @default.
• W2098264989 countsByYear W20982649892017 @default.
• W2098264989 countsByYear W20982649892020 @default.
• W2098264989 countsByYear W20982649892021 @default.
• W2098264989 countsByYear W20982649892023 @default.
• W2098264989 crossrefType "journal-article" @default.
• W2098264989 hasAuthorship W2098264989A5043019129 @default.
• W2098264989 hasAuthorship W2098264989A5058001992 @default.
• W2098264989 hasConcept C112446052 @default.
• W2098264989 hasConcept C126322002 @default.
• W2098264989 hasConcept C134018914 @default.
• W2098264989 hasConcept C153911025 @default.
• W2098264989 hasConcept C178790620 @default.
• W2098264989 hasConcept C184235292 @default.
• W2098264989 hasConcept C185592680 @default.
• W2098264989 hasConcept C195794163 @default.
• W2098264989 hasConcept C2777391703 @default.
• W2098264989 hasConcept C2779133857 @default.
• W2098264989 hasConcept C2779306644 @default.
• W2098264989 hasConcept C2780043322 @default.
• W2098264989 hasConcept C537181965 @default.
• W2098264989 hasConcept C57074206 @default.
• W2098264989 hasConcept C62478195 @default.
• W2098264989 hasConcept C71924100 @default.
• W2098264989 hasConcept C86554907 @default.
• W2098264989 hasConcept C86803240 @default.
• W2098264989 hasConcept C95444343 @default.
• W2098264989 hasConcept C97029542 @default.
• W2098264989 hasConceptScore W2098264989C112446052 @default.
• W2098264989 hasConceptScore W2098264989C126322002 @default.
• W2098264989 hasConceptScore W2098264989C134018914 @default.
• W2098264989 hasConceptScore W2098264989C153911025 @default.
• W2098264989 hasConceptScore W2098264989C178790620 @default.
• W2098264989 hasConceptScore W2098264989C184235292 @default.
• W2098264989 hasConceptScore W2098264989C185592680 @default.
• W2098264989 hasConceptScore W2098264989C195794163 @default.
• W2098264989 hasConceptScore W2098264989C2777391703 @default.
• W2098264989 hasConceptScore W2098264989C2779133857 @default.
• W2098264989 hasConceptScore W2098264989C2779306644 @default.
• W2098264989 hasConceptScore W2098264989C2780043322 @default.
• W2098264989 hasConceptScore W2098264989C537181965 @default.
• W2098264989 hasConceptScore W2098264989C57074206 @default.
• W2098264989 hasConceptScore W2098264989C62478195 @default.
• W2098264989 hasConceptScore W2098264989C71924100 @default.
• W2098264989 hasConceptScore W2098264989C86554907 @default.
• W2098264989 hasConceptScore W2098264989C86803240 @default.
• W2098264989 hasConceptScore W2098264989C95444343 @default.
• W2098264989 hasConceptScore W2098264989C97029542 @default.
• W2098264989 hasIssue "4" @default.

• next