FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098265440> ?p ?o ?g. }

• W2098265440 endingPage "380" @default.
• W2098265440 startingPage "372" @default.
• W2098265440 abstract "Melanoma progression is a multistep progression from a common melanocytic nevus through the radial growth phase, the invasive vertical growth phase finally leading to metastatic spread into distant organs. Migration and invasion of tumor cells requires secretion of proteases to facilitate remodeling of the extracellular matrix including basement membranes. Here we used a reconstructed skin model to investigate melanoma growth and invasion in vitro. Using this model we show that the dermoepidermal basement membrane prevents the invasion of metastatic melanoma BLM and MV3 cells in the absence of a stratified epidermis. In the reconstructed skin model, matrix metalloproteinase-9, a protease activated early in melanoma development, is secreted by the keratinocytes and subsequently activated by an unknown soluble factor secreted by the melanoma cells. The dynamic interplay between keratinocytes and melanoma cells is further shown by an altered growth pattern of melanoma cells and the finding that a reconstructed epidermis induces invasion. Overall, our findings show that the invasive behavior of melanoma cells is determined by the melanoma cells themselves, but that the interplay between surrounding keratinocytes and the melanoma cells plays an important role in melanoma invasion." @default.
• W2098265440 created "2016-06-24" @default.
• W2098265440 creator A5019294769 @default.
• W2098265440 creator A5023416000 @default.
• W2098265440 creator A5059022065 @default.
• W2098265440 creator A5078365930 @default.
• W2098265440 creator A5090190957 @default.
• W2098265440 date "2010-10-01" @default.
• W2098265440 modified "2023-10-02" @default.
• W2098265440 title "Keratinocytes drive melanoma invasion in a reconstructed skin model" @default.
• W2098265440 cites W1503337666 @default.
• W2098265440 cites W1574172480 @default.
• W2098265440 cites W1644093871 @default.
• W2098265440 cites W1967009719 @default.
• W2098265440 cites W1972938030 @default.
• W2098265440 cites W1987209094 @default.
• W2098265440 cites W1996067072 @default.
• W2098265440 cites W2000731779 @default.
• W2098265440 cites W2003500892 @default.
• W2098265440 cites W2005696755 @default.
• W2098265440 cites W2010715204 @default.
• W2098265440 cites W2012068830 @default.
• W2098265440 cites W2035602414 @default.
• W2098265440 cites W2040087271 @default.
• W2098265440 cites W2046235643 @default.
• W2098265440 cites W2056802402 @default.
• W2098265440 cites W2071507111 @default.
• W2098265440 cites W2075824380 @default.
• W2098265440 cites W2086770179 @default.
• W2098265440 cites W2086902361 @default.
• W2098265440 cites W2087988834 @default.
• W2098265440 cites W2109017823 @default.
• W2098265440 cites W2129091609 @default.
• W2098265440 cites W2137705897 @default.
• W2098265440 cites W2142712506 @default.
• W2098265440 cites W2152099942 @default.
• W2098265440 cites W2170862003 @default.
• W2098265440 cites W2172053587 @default.
• W2098265440 cites W4244068819 @default.
• W2098265440 doi "https://doi.org/10.1097/cmr.0b013e32833d8d70" @default.
• W2098265440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20700063" @default.
• W2098265440 hasPublicationYear "2010" @default.
• W2098265440 type Work @default.
• W2098265440 sameAs 2098265440 @default.
• W2098265440 citedByCount "30" @default.
• W2098265440 countsByYear W20982654402012 @default.
• W2098265440 countsByYear W20982654402013 @default.
• W2098265440 countsByYear W20982654402014 @default.
• W2098265440 countsByYear W20982654402015 @default.
• W2098265440 countsByYear W20982654402016 @default.
• W2098265440 countsByYear W20982654402017 @default.
• W2098265440 countsByYear W20982654402019 @default.
• W2098265440 countsByYear W20982654402020 @default.
• W2098265440 countsByYear W20982654402021 @default.
• W2098265440 countsByYear W20982654402022 @default.
• W2098265440 countsByYear W20982654402023 @default.
• W2098265440 crossrefType "journal-article" @default.
• W2098265440 hasAuthorship W2098265440A5019294769 @default.
• W2098265440 hasAuthorship W2098265440A5023416000 @default.
• W2098265440 hasAuthorship W2098265440A5059022065 @default.
• W2098265440 hasAuthorship W2098265440A5078365930 @default.
• W2098265440 hasAuthorship W2098265440A5090190957 @default.
• W2098265440 hasConcept C105702510 @default.
• W2098265440 hasConcept C109523444 @default.
• W2098265440 hasConcept C142724271 @default.
• W2098265440 hasConcept C189165786 @default.
• W2098265440 hasConcept C2776193487 @default.
• W2098265440 hasConcept C2776458125 @default.
• W2098265440 hasConcept C2777658100 @default.
• W2098265440 hasConcept C2780589465 @default.
• W2098265440 hasConcept C502942594 @default.
• W2098265440 hasConcept C55493867 @default.
• W2098265440 hasConcept C71924100 @default.
• W2098265440 hasConcept C86803240 @default.
• W2098265440 hasConcept C95444343 @default.
• W2098265440 hasConceptScore W2098265440C105702510 @default.
• W2098265440 hasConceptScore W2098265440C109523444 @default.
• W2098265440 hasConceptScore W2098265440C142724271 @default.
• W2098265440 hasConceptScore W2098265440C189165786 @default.
• W2098265440 hasConceptScore W2098265440C2776193487 @default.
• W2098265440 hasConceptScore W2098265440C2776458125 @default.
• W2098265440 hasConceptScore W2098265440C2777658100 @default.
• W2098265440 hasConceptScore W2098265440C2780589465 @default.
• W2098265440 hasConceptScore W2098265440C502942594 @default.
• W2098265440 hasConceptScore W2098265440C55493867 @default.
• W2098265440 hasConceptScore W2098265440C71924100 @default.
• W2098265440 hasConceptScore W2098265440C86803240 @default.
• W2098265440 hasConceptScore W2098265440C95444343 @default.
• W2098265440 hasIssue "5" @default.
• W2098265440 hasLocation W20982654401 @default.
• W2098265440 hasLocation W20982654402 @default.
• W2098265440 hasOpenAccess W2098265440 @default.
• W2098265440 hasPrimaryLocation W20982654401 @default.
• W2098265440 hasRelatedWork W1494554257 @default.
• W2098265440 hasRelatedWork W2041369649 @default.
• W2098265440 hasRelatedWork W2091139028 @default.
• W2098265440 hasRelatedWork W2106761248 @default.
• W2098265440 hasRelatedWork W2164377027 @default.

• next