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• W2098265722 endingPage "12900" @default.
• W2098265722 startingPage "12895" @default.
• W2098265722 abstract "It is well established that CD4 + CD8 + thymocytes are more sensitive to myriad death stimuli than CD4 + or CD8 + single positive (SP) thymocytes. The mechanism behind this hypersensitivity to apoptosis of CD4 + CD8 + thymocytes is not understood. To test whether the difference lay in the apoptotic preset of mitochondria, established by the BCL-2 family of proteins, we developed a method, FACS-based BH3 profiling. Using this tool, we could discriminate thymocyte subpopulations and demonstrate that mitochondria in double positive (DP) thymocytes are more primed for death than those in single positive counterparts. Loss of proapoptotic BIM, known to cause autoimmunity, also causes loss of “priming.” Priming is a phenotype with physiologic consequences, which can be measured at the single-cell level in complex samples using FACS-based BH3 profiling." @default.
• W2098265722 created "2016-06-24" @default.
• W2098265722 creator A5020205427 @default.
• W2098265722 creator A5022857112 @default.
• W2098265722 creator A5055160574 @default.
• W2098265722 date "2010-07-06" @default.
• W2098265722 modified "2023-10-17" @default.
• W2098265722 title "Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4⁺CD8⁺thymocytes" @default.
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• W2098265722 doi "https://doi.org/10.1073/pnas.0914878107" @default.
• W2098265722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2919900" @default.
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• W2098265722 hasPublicationYear "2010" @default.
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