FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098273035> ?p ?o ?g. }

• W2098273035 endingPage "388" @default.
• W2098273035 startingPage "377" @default.
• W2098273035 abstract "Green tea has been reported as potential dietary protection against numerous cancers and has been shown to have activity in bladder tumor inhibition in different animal models. The goal of this study was to examine the effects of (−)-epigallocatechin gallate (EGCG—the major phytochemical in green tea) on growth inhibition and behavior of human bladder carcinoma cells and to identify the altered signaling pathway(s) underlying the response to EGCG exposure. EGCG inhibited the in vitro growth of invasive bladder carcinoma cells with an IC50 range of 70–87 µM. At a concentration of 20 µM, EGCG decreased the migratory potential of bladder carcinoma cells with concomitant activation of p42/44 MAPK and STAT3 and inactivation of Akt. Using biochemical inhibitors of MAPK/ERK, and siRNA to knockdown STAT3 and Akt, inhibition of migration was recorded associated with Akt but not MAPK/ERK or STAT3 signaling in bladder cells. In addition, EGCG downregulated N-cadherin in a dose-dependent manner where reduction in N-cadherin expression paralleled declining migratory potential. Continuous feeding of EGCG to mice prior to and during the establishment of bladder carcinoma xenografts in vivo revealed >50% reduction in mean final tumor volume (P ≤ 0.05) with no detectable toxicity. EGCG inhibited bladder carcinoma cell growth and suppressed the in vitro migration capacity of cells via downregulation of N-cadherin and inactivation of Akt signaling. Continuous administration of EGCG to mice revealed significant inhibition of tumor growth in vivo indicating a possible preventative role for green tea in bladder cancer. J. Cell. Biochem. 102: 377–388, 2007. © 2007 Wiley-Liss, Inc." @default.
• W2098273035 created "2016-06-24" @default.
• W2098273035 creator A5006546115 @default.
• W2098273035 creator A5011999206 @default.
• W2098273035 creator A5018016162 @default.
• W2098273035 creator A5024039757 @default.
• W2098273035 creator A5029226730 @default.
• W2098273035 creator A5029582174 @default.
• W2098273035 creator A5038541048 @default.
• W2098273035 creator A5041792310 @default.
• W2098273035 creator A5054023133 @default.
• W2098273035 creator A5083571909 @default.
• W2098273035 creator A5086854638 @default.
• W2098273035 creator A5091328128 @default.
• W2098273035 date "2007-01-01" @default.
• W2098273035 modified "2023-10-17" @default.
• W2098273035 title "The green tea compound, (−)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells" @default.
• W2098273035 cites W1486221931 @default.
• W2098273035 cites W1487591190 @default.
• W2098273035 cites W1578523240 @default.
• W2098273035 cites W1602236522 @default.
• W2098273035 cites W1965805525 @default.
• W2098273035 cites W1965962153 @default.
• W2098273035 cites W1971873096 @default.
• W2098273035 cites W1973244778 @default.
• W2098273035 cites W1974623964 @default.
• W2098273035 cites W1977681992 @default.
• W2098273035 cites W1980304033 @default.
• W2098273035 cites W1995141996 @default.
• W2098273035 cites W2000621575 @default.
• W2098273035 cites W2007042842 @default.
• W2098273035 cites W2009850143 @default.
• W2098273035 cites W2010719972 @default.
• W2098273035 cites W2016654987 @default.
• W2098273035 cites W2016998573 @default.
• W2098273035 cites W2025903599 @default.
• W2098273035 cites W2029085730 @default.
• W2098273035 cites W2040636059 @default.
• W2098273035 cites W2045939602 @default.
• W2098273035 cites W2048859720 @default.
• W2098273035 cites W2050451392 @default.
• W2098273035 cites W2056961869 @default.
• W2098273035 cites W2058153177 @default.
• W2098273035 cites W2062120996 @default.
• W2098273035 cites W2068598785 @default.
• W2098273035 cites W2068684928 @default.
• W2098273035 cites W2069736913 @default.
• W2098273035 cites W2069989301 @default.
• W2098273035 cites W2072188289 @default.
• W2098273035 cites W2075851548 @default.
• W2098273035 cites W2078776487 @default.
• W2098273035 cites W2082341926 @default.
• W2098273035 cites W2102411854 @default.
• W2098273035 cites W2103498170 @default.
• W2098273035 cites W2107673483 @default.
• W2098273035 cites W2125329352 @default.
• W2098273035 cites W2139695381 @default.
• W2098273035 cites W2148033621 @default.
• W2098273035 cites W2156639218 @default.
• W2098273035 cites W2168132502 @default.
• W2098273035 cites W4237272845 @default.
• W2098273035 doi "https://doi.org/10.1002/jcb.21299" @default.
• W2098273035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17348027" @default.
• W2098273035 hasPublicationYear "2007" @default.
• W2098273035 type Work @default.
• W2098273035 sameAs 2098273035 @default.
• W2098273035 citedByCount "33" @default.
• W2098273035 countsByYear W20982730352012 @default.
• W2098273035 countsByYear W20982730352013 @default.
• W2098273035 countsByYear W20982730352014 @default.
• W2098273035 countsByYear W20982730352016 @default.
• W2098273035 countsByYear W20982730352018 @default.
• W2098273035 countsByYear W20982730352019 @default.
• W2098273035 countsByYear W20982730352020 @default.
• W2098273035 countsByYear W20982730352021 @default.
• W2098273035 crossrefType "journal-article" @default.
• W2098273035 hasAuthorship W2098273035A5006546115 @default.
• W2098273035 hasAuthorship W2098273035A5011999206 @default.
• W2098273035 hasAuthorship W2098273035A5018016162 @default.
• W2098273035 hasAuthorship W2098273035A5024039757 @default.
• W2098273035 hasAuthorship W2098273035A5029226730 @default.
• W2098273035 hasAuthorship W2098273035A5029582174 @default.
• W2098273035 hasAuthorship W2098273035A5038541048 @default.
• W2098273035 hasAuthorship W2098273035A5041792310 @default.
• W2098273035 hasAuthorship W2098273035A5054023133 @default.
• W2098273035 hasAuthorship W2098273035A5083571909 @default.
• W2098273035 hasAuthorship W2098273035A5086854638 @default.
• W2098273035 hasAuthorship W2098273035A5091328128 @default.
• W2098273035 hasConcept C150903083 @default.
• W2098273035 hasConcept C185592680 @default.
• W2098273035 hasConcept C207001950 @default.
• W2098273035 hasConcept C2778923194 @default.
• W2098273035 hasConcept C502942594 @default.
• W2098273035 hasConcept C55493867 @default.
• W2098273035 hasConcept C57074206 @default.
• W2098273035 hasConcept C62112901 @default.
• W2098273035 hasConcept C62478195 @default.
• W2098273035 hasConcept C75217442 @default.

• next