FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098280548> ?p ?o ?g. }

• W2098280548 endingPage "355" @default.
• W2098280548 startingPage "351" @default.
• W2098280548 abstract "Neprilysin (NEP) is one of the candidate amyloid β protein (Aβ) degrading enzymes affecting brain Aβ clearance. This enzyme declines in the brain with age, which leads to the increased Aβ deposition in Alzheimer’s disease (AD). Pharmacological activation of NEP during the aging process, therefore, represents a potential strategy to prevent the development of AD. To examine the influence of nobiletin on neprilysin activity, we measured cellular NEP activity in SK-N-SH cells. Moreover, NEP expression was examined by using reverse transcription – polymerase chain reaction and Western blotting. Measurement of cellular NEP activity showed that nobiletin stimulated this in a dose- and time-dependent manner in SK-N-SH cells. Moreover, nobiletin increased the expression of NEP mRNA, and then the levels of NEP protein, also in a dose- and time-dependent manner. Our findings showed that nobiletin promoted NEP gene and protein expression, resulting in enhancement of cellular NEP activity in SK-N-SH cells. This compound could be a novel Aβ-degrading compound for use in the development of disease-modifying drugs to prevent and (or) cure AD." @default.
• W2098280548 created "2016-06-24" @default.
• W2098280548 creator A5021060116 @default.
• W2098280548 creator A5036608548 @default.
• W2098280548 creator A5058844285 @default.
• W2098280548 creator A5059199772 @default.
• W2098280548 creator A5065133468 @default.
• W2098280548 creator A5079882445 @default.
• W2098280548 creator A5080057915 @default.
• W2098280548 creator A5088379836 @default.
• W2098280548 date "2014-05-01" @default.
• W2098280548 modified "2023-10-14" @default.
• W2098280548 title "Nobiletin, a flavone from <i>Citrus depressa</i>, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells" @default.
• W2098280548 cites W1967408430 @default.
• W2098280548 cites W1971951016 @default.
• W2098280548 cites W1978048796 @default.
• W2098280548 cites W1978115007 @default.
• W2098280548 cites W1985772936 @default.
• W2098280548 cites W2012630384 @default.
• W2098280548 cites W2016436495 @default.
• W2098280548 cites W2029532449 @default.
• W2098280548 cites W2030011352 @default.
• W2098280548 cites W2035164721 @default.
• W2098280548 cites W2045734671 @default.
• W2098280548 cites W2045782431 @default.
• W2098280548 cites W2070342882 @default.
• W2098280548 cites W2082693269 @default.
• W2098280548 cites W2089311308 @default.
• W2098280548 cites W2092788481 @default.
• W2098280548 cites W2093552070 @default.
• W2098280548 cites W2120234533 @default.
• W2098280548 cites W2143898521 @default.
• W2098280548 cites W2153966730 @default.
• W2098280548 cites W2168334242 @default.
• W2098280548 cites W2169799732 @default.
• W2098280548 cites W2414929465 @default.
• W2098280548 doi "https://doi.org/10.1139/cjpp-2013-0440" @default.
• W2098280548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24784468" @default.
• W2098280548 hasPublicationYear "2014" @default.
• W2098280548 type Work @default.
• W2098280548 sameAs 2098280548 @default.
• W2098280548 citedByCount "13" @default.
• W2098280548 countsByYear W20982805482014 @default.
• W2098280548 countsByYear W20982805482015 @default.
• W2098280548 countsByYear W20982805482016 @default.
• W2098280548 countsByYear W20982805482017 @default.
• W2098280548 countsByYear W20982805482018 @default.
• W2098280548 countsByYear W20982805482019 @default.
• W2098280548 countsByYear W20982805482021 @default.
• W2098280548 crossrefType "journal-article" @default.
• W2098280548 hasAuthorship W2098280548A5021060116 @default.
• W2098280548 hasAuthorship W2098280548A5036608548 @default.
• W2098280548 hasAuthorship W2098280548A5058844285 @default.
• W2098280548 hasAuthorship W2098280548A5059199772 @default.
• W2098280548 hasAuthorship W2098280548A5065133468 @default.
• W2098280548 hasAuthorship W2098280548A5079882445 @default.
• W2098280548 hasAuthorship W2098280548A5080057915 @default.
• W2098280548 hasAuthorship W2098280548A5088379836 @default.
• W2098280548 hasConcept C104317684 @default.
• W2098280548 hasConcept C104826730 @default.
• W2098280548 hasConcept C105580179 @default.
• W2098280548 hasConcept C150194340 @default.
• W2098280548 hasConcept C153911025 @default.
• W2098280548 hasConcept C181199279 @default.
• W2098280548 hasConcept C185592680 @default.
• W2098280548 hasConcept C2778004101 @default.
• W2098280548 hasConcept C2778401301 @default.
• W2098280548 hasConcept C2779054382 @default.
• W2098280548 hasConcept C55493867 @default.
• W2098280548 hasConcept C85265743 @default.
• W2098280548 hasConcept C86803240 @default.
• W2098280548 hasConcept C95444343 @default.
• W2098280548 hasConceptScore W2098280548C104317684 @default.
• W2098280548 hasConceptScore W2098280548C104826730 @default.
• W2098280548 hasConceptScore W2098280548C105580179 @default.
• W2098280548 hasConceptScore W2098280548C150194340 @default.
• W2098280548 hasConceptScore W2098280548C153911025 @default.
• W2098280548 hasConceptScore W2098280548C181199279 @default.
• W2098280548 hasConceptScore W2098280548C185592680 @default.
• W2098280548 hasConceptScore W2098280548C2778004101 @default.
• W2098280548 hasConceptScore W2098280548C2778401301 @default.
• W2098280548 hasConceptScore W2098280548C2779054382 @default.
• W2098280548 hasConceptScore W2098280548C55493867 @default.
• W2098280548 hasConceptScore W2098280548C85265743 @default.
• W2098280548 hasConceptScore W2098280548C86803240 @default.
• W2098280548 hasConceptScore W2098280548C95444343 @default.
• W2098280548 hasIssue "5" @default.
• W2098280548 hasLocation W20982805481 @default.
• W2098280548 hasLocation W20982805482 @default.
• W2098280548 hasOpenAccess W2098280548 @default.
• W2098280548 hasPrimaryLocation W20982805481 @default.
• W2098280548 hasRelatedWork W1972541767 @default.
• W2098280548 hasRelatedWork W2009966535 @default.
• W2098280548 hasRelatedWork W2098280548 @default.
• W2098280548 hasRelatedWork W2171277769 @default.
• W2098280548 hasRelatedWork W2223718544 @default.
• W2098280548 hasRelatedWork W2348091059 @default.
• W2098280548 hasRelatedWork W2352485591 @default.

• next