FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098315492> ?p ?o ?g. }

• W2098315492 endingPage "148" @default.
• W2098315492 startingPage "137" @default.
• W2098315492 abstract "Background Cyclin kinase subunit-2 (Cks2), a member of the human Cks family, plays an important role in the regulation of meiosis and mitosis; and its abnormal expression is usually associated with carcinogenesis. However, its exact functions and molecular mechanisms remain unclear. Aims To observe Cks2 expression in cholangiocarcinoma and explore its role in the carcinogenesis of cholangiocarcinoma and possible mechanism. Methods Cks2 expression in cholangiocarcinoma was detected with immunostaining and RT-PCR. MTT, colony formation, immunofluorescence, flow cytometry and Western blotting were performed to explore the role of Cks2 in cholangiocarcinoma and possible mechanism. Results Cks2 was significantly elevated in cholangiocarcinoma tissues and its over-expression was associated with poor differentiation, CA19-9 and poor prognosis. Furthermore, Cks2 down-regulation inhibited cholangiocarcinoma cell proliferation and colony formation in vitro, and the growth of cholangiocarcinoma xenografts in animals; especially, enhanced the sensitivity of cholangiocarcinoma cells to chemotherapy. We further found that Cks2 knockdown induced cholangiocarcinoma cell cycle arrest in G2/M phase through down-regulation of Cyclin A and Cyclin B1 and Bax up-regulation and activation, mitochondrial membrane permeabilization and caspase-3 activation, which resulted in facilitating cholangiocarcinoma apoptosis. Conclusions These findings suggest that Cks2 may serve as an independent prognostic factor in patients with cholangiocarcinoma, and play an important role in the carcinogenesis of cholangiocarcinoma by facilitating cell cycle progression and Bax-mediated mitochondrial caspase-dependent apoptosis." @default.
• W2098315492 created "2016-06-24" @default.
• W2098315492 creator A5007264715 @default.
• W2098315492 creator A5025676824 @default.
• W2098315492 creator A5043439435 @default.
• W2098315492 creator A5052725471 @default.
• W2098315492 creator A5057025677 @default.
• W2098315492 date "2012-11-01" @default.
• W2098315492 modified "2023-10-18" @default.
• W2098315492 title "Oncogenic potential of Cyclin Kinase Subunit-2 in cholangiocarcinoma" @default.
• W2098315492 cites W1573825647 @default.
• W2098315492 cites W1577840857 @default.
• W2098315492 cites W1964813626 @default.
• W2098315492 cites W1970368087 @default.
• W2098315492 cites W1973435955 @default.
• W2098315492 cites W1984547206 @default.
• W2098315492 cites W1988135978 @default.
• W2098315492 cites W1999630076 @default.
• W2098315492 cites W2015188954 @default.
• W2098315492 cites W2048974994 @default.
• W2098315492 cites W2054566387 @default.
• W2098315492 cites W2067316851 @default.
• W2098315492 cites W2070727316 @default.
• W2098315492 cites W2086900713 @default.
• W2098315492 cites W2088322370 @default.
• W2098315492 cites W2089707059 @default.
• W2098315492 cites W2092825834 @default.
• W2098315492 cites W2107129910 @default.
• W2098315492 cites W2124631712 @default.
• W2098315492 cites W2130145624 @default.
• W2098315492 cites W2150169404 @default.
• W2098315492 cites W2150231804 @default.
• W2098315492 cites W2157684646 @default.
• W2098315492 cites W2322978309 @default.
• W2098315492 cites W4234577872 @default.
• W2098315492 doi "https://doi.org/10.1111/liv.12014" @default.
• W2098315492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23121546" @default.
• W2098315492 hasPublicationYear "2012" @default.
• W2098315492 type Work @default.
• W2098315492 sameAs 2098315492 @default.
• W2098315492 citedByCount "32" @default.
• W2098315492 countsByYear W20983154922013 @default.
• W2098315492 countsByYear W20983154922014 @default.
• W2098315492 countsByYear W20983154922015 @default.
• W2098315492 countsByYear W20983154922016 @default.
• W2098315492 countsByYear W20983154922017 @default.
• W2098315492 countsByYear W20983154922018 @default.
• W2098315492 countsByYear W20983154922019 @default.
• W2098315492 countsByYear W20983154922020 @default.
• W2098315492 countsByYear W20983154922021 @default.
• W2098315492 countsByYear W20983154922022 @default.
• W2098315492 countsByYear W20983154922023 @default.
• W2098315492 crossrefType "journal-article" @default.
• W2098315492 hasAuthorship W2098315492A5007264715 @default.
• W2098315492 hasAuthorship W2098315492A5025676824 @default.
• W2098315492 hasAuthorship W2098315492A5043439435 @default.
• W2098315492 hasAuthorship W2098315492A5052725471 @default.
• W2098315492 hasAuthorship W2098315492A5057025677 @default.
• W2098315492 hasConcept C120089663 @default.
• W2098315492 hasConcept C120504264 @default.
• W2098315492 hasConcept C121608353 @default.
• W2098315492 hasConcept C173396325 @default.
• W2098315492 hasConcept C190283241 @default.
• W2098315492 hasConcept C2778437423 @default.
• W2098315492 hasConcept C29537977 @default.
• W2098315492 hasConcept C502942594 @default.
• W2098315492 hasConcept C54355233 @default.
• W2098315492 hasConcept C555283112 @default.
• W2098315492 hasConcept C62112901 @default.
• W2098315492 hasConcept C86803240 @default.
• W2098315492 hasConceptScore W2098315492C120089663 @default.
• W2098315492 hasConceptScore W2098315492C120504264 @default.
• W2098315492 hasConceptScore W2098315492C121608353 @default.
• W2098315492 hasConceptScore W2098315492C173396325 @default.
• W2098315492 hasConceptScore W2098315492C190283241 @default.
• W2098315492 hasConceptScore W2098315492C2778437423 @default.
• W2098315492 hasConceptScore W2098315492C29537977 @default.
• W2098315492 hasConceptScore W2098315492C502942594 @default.
• W2098315492 hasConceptScore W2098315492C54355233 @default.
• W2098315492 hasConceptScore W2098315492C555283112 @default.
• W2098315492 hasConceptScore W2098315492C62112901 @default.
• W2098315492 hasConceptScore W2098315492C86803240 @default.
• W2098315492 hasFunder F4320321001 @default.
• W2098315492 hasIssue "1" @default.
• W2098315492 hasLocation W20983154921 @default.
• W2098315492 hasLocation W20983154922 @default.
• W2098315492 hasOpenAccess W2098315492 @default.
• W2098315492 hasPrimaryLocation W20983154921 @default.
• W2098315492 hasRelatedWork W1972509069 @default.
• W2098315492 hasRelatedWork W1996748244 @default.
• W2098315492 hasRelatedWork W2005927939 @default.
• W2098315492 hasRelatedWork W2017808300 @default.
• W2098315492 hasRelatedWork W2354932337 @default.
• W2098315492 hasRelatedWork W2366424044 @default.
• W2098315492 hasRelatedWork W2377060024 @default.
• W2098315492 hasRelatedWork W2410716846 @default.
• W2098315492 hasRelatedWork W3197342850 @default.
• W2098315492 hasRelatedWork W4383711253 @default.

• next